Synthesis and antitumor activity of gold(I) N-heterocyclic carbene with dithiocarbamate and alkynyl complexes

被引：3
|
作者：
Chen, Qiu Mei [1 ]
Zeng, Yanyan [2 ]
Zhang, Ming Rui [1 ]
Jin, Lingyu [2 ]
Zhou, Ping [2 ]
Wu, Xiang Hua [1 ]
Ren, Wen Xiu [2 ]
机构：
[1] Yunnan Normal Univ, Coll Chem & Chem Engn, Kunming 650500, Peoples R China
[2] Southwest Med Univ, Dept Radiol, Affiliated Hosp, Luzhou 646000, Peoples R China
来源：
INORGANICA CHIMICA ACTA | 2024年 / 568卷
关键词：
N -heterocyclic carbene; Dithiocarbamate; Alkynyl; Gold(I) complex; Cytotoxic activity; TrxR; THIOREDOXIN REDUCTASE INHIBITORS; IN-VITRO; ANTICANCER ACTIVITY; LIGANDS; PAEONOL; CANCER;
D O I：
10.1016/j.ica.2024.122085
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of new type gold(I) N-heterocyclic carbene (NHC) complexes bearing a paeonol ligand in the side chain of NHC and bearing dithiocarbamate or alkynyl groups as a second ligand have been synthesized and structurally characterized by spectroscopic methods. The structure of Pa-NHC-Au-Cl has been established by X-ray crystallography. Their antitumor activities in vitro were investigated by CCK8 assay against two tumor cell lines (A549 and Hela). The gold(I) NHC with dithiocarbamate (DTC) complexes showed good to excellent antiproliferative activity and strongly inhibited the selenoenzyme thioredoxin reductase (TrxR).
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页数：5
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