Synthetic biology for Taxol biosynthesis and sustainable production

被引：1

作者：

Xie, Linfeng ^{[1
,2
]}

Gao, Jiaoqi ^{[1
,3
]}

Zhou, Yongjin J. ^{[1
,3
,4
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, 457 Zhongshan Rd, Dalian 116023, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

[4] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Key Lab Energy Biotechnol, 457 Zhongshan Rd, Dalian 116023, Peoples R China

来源：

TRENDS IN BIOTECHNOLOGY | 2024年 / 42卷 / 06期

关键词：

D O I：

10.1016/j.tibtech.2024.04.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Incomplete understanding of the biosynthetic pathway of the anticancer compound Taxol hinders its production by metabolic engineering. Recent reports by Jiang et al. and other groups now describe the missing steps in Taxol biosynthesis, notably including oxetane ring formation. These findings will promote the sustainable production of Taxol through synthetic biology.

引用

页码：674 / 676

页数：3

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