Discovery of potent and selective novel small molecule drugs to target estrogen receptor mutants in endocrine-resistant breast cancer

被引：0
|
作者：
Devakrishnan, Anil Kumar
Madasu, Chandrashekhar
Fuqua, Suzanne A. W.
Matzuk, Martin M.
Palaniappan, Murugesan
机构：
来源：
CANCER RESEARCH | 2024年 / 84卷 / 06期
关键词：
D O I：
10.1158/1538-7445.AM2024-6576
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
6576
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
    Joanna Achinger-Kawecka
    Fatima Valdes-Mora
    Phuc-Loi Luu
    Katherine A. Giles
    C. Elizabeth Caldon
    Wenjia Qu
    Shalima Nair
    Sebastian Soto
    Warwick J. Locke
    Nicole S. Yeo-Teh
    Cathryn M. Gould
    Qian Du
    Grady C. Smith
    Irene R. Ramos
    Kristine F. Fernandez
    Dave S. Hoon
    Julia M. W. Gee
    Clare Stirzaker
    Susan J. Clark
    Nature Communications, 11
  • [42] Changes in expression of estrogen receptor and coregulatory proteins in the acquisition of endocrine-resistant breast cancer, as demonstrated using an in vitro cell model.
    Parkes, A
    Ponchel, F
    Burdall, S
    Farmery, S
    Speirs, V
    BRITISH JOURNAL OF CANCER, 2002, 86 : S22 - S22
  • [43] Discovery of novel small molecule drugs against pancreatic cancer
    Wang, Yan
    Maeda, Yoshiko
    Kaur, Inderjeet
    Lam, Kit
    Kumaresan, Pappanaicken
    CANCER RESEARCH, 2009, 69
  • [44] Epigenetic reprogramming at estrogen-receptor binding sites alters 3D chromatin landscape in endocrine-resistant breast cancer
    Achinger-Kawecka, Joanna
    Valdes-Mora, Fatima
    Luu, Phuc-Loi
    Giles, Katherine A.
    Caldon, C. Elizabeth
    Qu, Wenjia
    Nair, Shalima
    Soto, Sebastian
    Locke, Warwick J.
    Yeo-Teh, Nicole S.
    Gould, Cathryn M.
    Du, Qian
    Smith, Grady C.
    Ramos, Irene R.
    Fernandez, Kristine F.
    Hoon, Dave S.
    Gee, Julia M. W.
    Stirzaker, Clare
    Clark, Susan J.
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [45] Genomic Landscape and Endocrine-Resistant Subgroup in Estrogen Receptor-Positive, Progesterone Receptor-Negative, and HER2-Negative Breast Cancer
    Liu, Xi-Yu
    Ma, Ding
    Xu, Xiao-En
    Jin, Xi
    Yu, Ke-Da
    Jiang, Yi-Zhou
    Shao, Zhi-Ming
    THERANOSTICS, 2018, 8 (22): : 6386 - 6399
  • [46] Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
    Tria, George S.
    Abrams, Tinya
    Baird, Jason
    Burks, Heather E.
    Firestone, Brant
    Gaither, L. Alex
    Hamann, Lawrence G.
    He, Guo
    Kirby, Christina A.
    Kim, Sunkyu
    Lombardo, Franco
    Macchi, Kaitlin J.
    McDonnell, Donald P.
    Mishina, Yuji
    Norris, John D.
    Nunez, Jill
    Springer, Clayton
    Sun, Yingchuan
    Thomsen, Noel M.
    Wang, Chunrong
    Wang, Jianling
    Yu, Bing
    Tiong-Yip, Choi-Lai
    Peukert, Stefan
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (07) : 2837 - 2864
  • [47] Novel drugs that target the estrogen-related receptor alpha: their therapeutic potential in breast cancer
    May, Felicity E. B.
    CANCER MANAGEMENT AND RESEARCH, 2014, 6 : 225 - 252
  • [48] PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
    Fan, Ping
    Jordan, V. Craig
    MOLECULAR CANCER RESEARCH, 2022, 20 (02) : 193 - 201
  • [49] Elacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer
    Pancholi, Sunil
    Simigdala, Nikiana
    Ribas, Ricardo
    Schuster, Eugene
    Leal, Mariana Ferreira
    Nikitorowicz-Buniak, Joanna
    Rega, Camilla
    Bihani, Teeru
    Patel, Hitisha
    Johnston, Stephen R.
    Dowsett, Mitch
    Martin, Lesley-Ann
    NPJ BREAST CANCER, 2022, 8 (01)
  • [50] Elacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer
    Sunil Pancholi
    Nikiana Simigdala
    Ricardo Ribas
    Eugene Schuster
    Mariana Ferreira Leal
    Joanna Nikitorowicz-Buniak
    Camilla Rega
    Teeru Bihani
    Hitisha Patel
    Stephen R. Johnston
    Mitch Dowsett
    Lesley-Ann Martin
    npj Breast Cancer, 8
12345