Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

被引：0

作者：

Rodriguez-Fernandez, Blanca ^{[1
,2
,3
,4
]}

Sanchez-Benavides, Gonzalo ^{[1
,2
,5
]}

Genius, Patricia ^{[1
,2
,3
]}

Minguillon, Carolina ^{[1
,2
,5
]}

Fauria, Karine ^{[1
,5
]}

De Vivo, Immaculata ^{[6
,7
]}

Navarro, Arcadi ^{[1
,3
,8
,9
]}

Molinuevo, Jose Luis ^{[1
,15
]}

Gispert, Juan Domingo ^{[1
,2
,10
,11
]}

Sala-Vila, Aleix ^{[1
,2
]}

Vilor-Tejedor, Natalia ^{[1
,2
,3
,12
,13
]}

Crous-Bou, Marta ^{[1
,5
,12
,14
]}

机构：

[1] Pasqual Maragall Fdn, Barcelonabeta Brain Res Ctr BBRC, C Wellington 30, Barcelona 08005, Spain

[2] IMIM Hosp del Mar Med Res Inst, C Dr Aiguader 88,2nd Floor,Campus Mar, Barcelona 08003, Spain

[3] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, C Dr Aiguader 88, Barcelona 08003, Spain

[4] Univ Autonoma Barcelona, Barcelona 08193, Spain

[5] Inst Salud Carlos III, Ctr Invest Biomed Red Fragilidad & Envejecimiento, C Monforte Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain

[6] Harvard TH Chan Sch Publ Hlth, Sch Publ Hlth 2, Dept Epidemiol, 677 Huntington Ave, Boston, MA 02115 USA

[7] Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA

[8] Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Pg Maritim Barceloneta 37, Barcelona 08003, Spain

[9] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain

[10] Inst Salud Carlos III, Ctr Invest Biomed Red Bioingn Biomat & Nanomed, C Monforte Lemos 3-5,Pabellon 11,Planta 0, Madrid 28029, Spain

[11] Ctr Nacl Invest Cardiovasc CNIC, C Melchor Fernandez Almagro 3, Madrid 28029, Spain

[12] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

[13] Univ Pompeu Fabra, C Ramon Trias Fargas 25,27, Barcelona 08005, Spain

[14] Hosp Duran & Reynals, Catalan Inst Oncol ICO, Bellvitge Biomed Res Ctr IDIBELL, Avinguda Granvia Hospitalet 199-203, Barcelona 08908, Spain

[15] H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Copenhagen, Denmark

来源：

NEUROBIOLOGY OF AGING | 2024年 / 141卷

关键词：

Alzheimer's disease; Biological aging; Cognitive performance; Sex differences; Telomere length; MINI-MENTAL STATE; METAANALYSIS; POPULATION; DEMENTIA; VERSION; RECALL; ADULTS;

D O I：

10.1016/j.neurobiolaging.2024.05.015

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.

引用

页码：140 / 150

页数：11

共 50 条

[21] Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
Nicholas C. Cullen
Antoine Leuzy
Shorena Janelidze
Sebastian Palmqvist
Anna L. Svenningsson
Erik Stomrud
Jeffrey L. Dage
Niklas Mattsson-Carlgren
Oskar Hansson
Nature Communications, 12
[22] Minimum spanning tree analysis of unimpaired individuals at risk of Alzheimer's disease
Garcia-Colomo, Alejandra
Lopez-Sanz, David
Stam, Cornelis J.
Hillebrand, Arjan
Carrasco-Gomez, Martin
Spuch, Carlos
Comis-Tuche, Maria
Maestu, Fernando
BRAIN COMMUNICATIONS, 2024, 6 (05)
[23] Plasma biomarkers of Alzheimer's disease improve prediction of cognitive decline in cognitively unimpaired elderly populations
Cullen, Nicholas C.
Leuzy, Antoine
Janelidze, Shorena
Palmqvist, Sebastian
Svenningsson, Anna L.
Stomrud, Erik
Dage, Jeffrey L.
Mattsson-Carlgren, Niklas
Hansson, Oskar
NATURE COMMUNICATIONS, 2021, 12 (01)
[24] Neuropsychiatric Symptoms and PET Markers of Alzheimer's Pathology in Cognitively-Unimpaired Individuals With Autosomal-Dominant Alzheimer's Disease
Gatchel, Jennifer
Lopera, Francisco
Norton, Daniel
Baena, Ana
Guzman-Velez, Edmarie
Schultz, Aaron
Johnson, Keith
Sperling, Reisa
Marshall, Gad
Quiroz, Yakeel
NEUROPSYCHOPHARMACOLOGY, 2017, 42 : S505 - S505
[25] Longitudinal association of depressive symptoms with cognition and neuroimaging biomarkers in cognitively unimpaired older adults, mild cognitive impairment, and Alzheimer's disease
Hu, Ying
Zhu, Ting
Yuan, Minlan
Zhu, Hongru
Zhang, Wei
CEREBRAL CORTEX, 2024, 34 (10)
[26] Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer's disease
Caputo, Angelika
Racine, Amy
Paule, Ines
Tariot, Pierre N.
Langbaum, Jessica B.
Coello, Neva
Riviere, Marie-Emmanuelle
Ryan, J. Michael
Lopez, Cristina Lopez
Graf, Ana
ALZHEIMERS RESEARCH & THERAPY, 2023, 15 (01)
[27] Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer’s disease
Angelika Caputo
Amy Racine
Ines Paule
Pierre N. Tariot
Jessica B. Langbaum
Neva Coello
Marie-Emmanuelle Riviere
J. Michael Ryan
Cristina Lopez Lopez
Ana Graf
Alzheimer's Research & Therapy, 15
[28] Classification of Alzheimer's Disease, Mild Cognitive Impairment, and Cognitively Unimpaired Individuals Using Multi-feature Kernel Discriminant Dictionary Learning
Li, Qing
Wu, Xia
Xu, Lele
Chen, Kewei
Yao, Li
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, 2018, 11
[29] Association of Leukocyte Telomere Length with Mild Cognitive Impairment and Alzheimer's Disease: Role of Folate and Homocysteine
Ma, Fei
Lv, Xin
Du, Yue
Chen, Hui
Liu, Shuai
Zhao, Jiangang
Gao, Yiming
An, Peilin
Zhou, Xuan
Song, Aili
Sun, Changqing
Wang, Guangshun
Ji, Yong
Wang, Xinyan
Xu, Weili
Huang, Guowei
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2019, 48 (1-2) : 56 - 67
[30] Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not β-Amyloid in Cognitively Normal Older Individuals
Wirth, Miranka
Madison, Cindee M.
Rabinovici, Gil D.
Oh, Hwamee
Landau, Susan M.
Jagust, William J.
JOURNAL OF NEUROSCIENCE, 2013, 33 (13): : 5553 - 5563

← 1 2 3 4 5 →