Atrial fibrillation and the risk of early-onset dementia and cognitive decline: An updated review

被引：9

作者：

Kogelschatz, Benjamin ^{[1
]}

Zenger, Brian ^{[1
]}

Steinberg, Benjamin A. ^{[1
]}

Ranjan, Ravi ^{[1
]}

Bunch, T. Jared ^{[1
]}

机构：

[1] Univ Utah, Hlth Sci Ctr, Div Cardiovasc Med, 30 North 1900 East, Room 4A100, Salt Lake City, UT 84132 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2024年 / 34卷 / 04期

关键词：

Atrial fibrillation; Stroke; Dementia; Anticoagulants; Catheter ablation; CATHETER ABLATION; LESS DEMENTIA; ASSOCIATION; VARIANTS; STROKE;

D O I：

10.1016/j.tcm.2023.01.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationship between atrial fibrillation (AF) and dementia has been well described; however, recent data suggest that AF confers a greater risk for the development of early-onset dementia irrespective of clinical stroke. Numerous mechanisms have been hypothesized to explain cognitive decline in the setting of AF, including silent cerebral ischemia, cerebral hypoperfusion, and cerebral microvascular disease. Despite the emergence of data supporting the increased risk of early-onset dementia in patients with AF, the underlying mechanism remains unclear. Furthermore, the mechanism may be influenced by survival bias, genetic susceptibility, or early dysfunction of brain adaptation. Investigation into why this relationship exists could change how prevention and treatment are evaluated. (c) 2023 Elsevier Inc. All rights reserved.

引用

页码：236 / 241

页数：6

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