Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach

A series of six novel polyesters (P 1 -P 6 ) were obtained via by direct polycondenzation with hydroxyl functionalappended chromone and curcumin based monomers ( M 1 , M 2 and M 3 ) were synthesized and subjected to thermogravimetric and spectroscopic analyses for structural characterization. The synthesized polymers were soluble common organic solvent such as DMF , THF, DMAc and 1-methyl-2-pyrrolidinone (NMP). The molecular weight of the polymers was found to be ranged from 3.390 x 10 5 - 1.1 x 10 5 g/mol by GPC-MALS. X-ray diffraction pattern of polyesters indicates P 1 , P 2 and P 3 are amorphous in nature, whereas polymer P 4 , P 5 , and P 6 shows crystalline nature. The receptor VEGFR2 kinase can expand the synthesized molecules into 2D and 3D supramolecular networking through 7C -7C stacking, hydrophobic, and H -bonding interactions. The cell viability effects of polymers on the growth of cell lines A549, HeLa and VERO were evaluated in vitro by MTT assay. The polymer P 3 displayed potent anticancer activity compared to the other polymers. Research is undergone in developing curcumin chromone functional polymer as a workable biopolymer which could find value in the present findings.