Regioselective Annulation of 3(5)-Aminopyrazole with Aryl Ketones or Aryl Alkynes Using N,N-Dimethylethanolamine as a Single/Triple Carbon Synthon

被引：3

作者：

Zhang, Xinyu ^{[1
,2
,3
]}

Chen, Jing ^{[3
]}

Chen, Rener ^{[1
,2
]}

Wang, Lei ^{[1
,2
,4
]}

Ma, Yongmin ^{[1
,2
,3
]}

机构：

[1] Taizhou Univ, Inst Adv Studies, Jiaojiang 318000, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut Sci, Jiaojiang, Zhejiang, Peoples R China

[3] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China

[4] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 311121, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 17期

关键词：

Triple carbon synthon; dimethylethanolamine; regioselective annulation; pyrazolo-pyrimidine; pyrazolo-pyridine; NITROGEN-HETEROCYCLES; BIOLOGICAL EVALUATION; DERIVATIVES; C(SP(3))-H; INHIBITORS; DISCOVERY; ARYLATION; C(SP(2))-H; CHEMISTRY; FACILE;

D O I：

10.1002/adsc.202400546

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient and regioselective cyclization for construction of pyrazolo[3,4-b]pyridines and methylene-bridged bis(pyrazolo[1,5-a]pyrimidines) has been established. It involves a [3+2+1] annulation of 3(5)-aminopyrazole, N,N-dimethylethanolamine (DMEA), with 1,2-insertion of aryl methyl ketones or 2,1-insertion of aryl alkynes. DMEA is oxidized through C(sp3)-H activation to provide a single or triple carbon source.

引用

页码：3591 / 3596

页数：6

共 49 条

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