Tinengotinib in patients with advanced solid tumors harboring actionable FGFR1-3 mutations

被引:0
|
作者
Piha-Paul, Sarina A.
Liao, Chih-Yi Andy
Fonkoua, Lionel
Mahipa, Amit, I
Goel, Sanjay
Fountzilas, Christos
Shen, Lin
Li, Daneng
Deming, Dustin
Dayyani, Farshid
Han, Weiqing
Niu, Zuoxing
Fan, Jean
Peng, Peng
Wang, Hui
Huang, Peng
Wu, Frank
Javle, Milind
机构
关键词
D O I
10.1158/1538-7445.AM2024-LB162
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LB162
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Phase 1/1b study evaluating KIN-3248, a next-generation, irreversible pan-FGFR inhibitor (FGFRi), in patients (pts) with advanced cholangiocarcinoma (CCA) and other solid tumors harboring FGFR2 and/or FGFR3 gene alterations
    Harding, J.
    Perez, C.
    Kato, S.
    Sharma, M.
    Garmezy, B.
    Quah, C.
    Tam, B.
    Severson, P.
    ANNALS OF ONCOLOGY, 2023, 34 : S63 - S64
  • [22] Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations
    Tyhonas, John S.
    Arnold, Lee D.
    Cox, Jason M.
    Franovic, Aleksandra
    Gardiner, Elisabeth
    Grandinetti, Kathryn
    Kania, Robert
    Kanouni, Toufike
    Lardy, Matthew
    Li, Chun
    Martin, Eric S.
    Miller, Nichol
    Mohan, Adithi
    Murphy, Eric A.
    Perez, Michelle
    Soroceanu, Liliana
    Timple, Noel
    Uryu, Sean
    Womble, Scott
    Kaldor, Stephen W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (03) : 1734 - 1746
  • [23] A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations
    Voss, Martin H.
    Hierro, Cinta
    Heist, Rebecca S.
    Cleary, James M.
    Meric-Bernstam, Funda
    Tabernero, Josep
    Janku, Filip
    Gandhi, Leena
    Iafrate, A. John
    Borger, Darrell R.
    Ishii, Nobuya
    Hu, Youyou
    Kirpicheva, Yulia
    Nicolas-Metral, Valerie
    Pokorska-Bocci, Anna
    Chessex, Anne Vaslin
    Zanna, Claudio
    Flaherty, Keith T.
    Baselga, Jose
    CLINICAL CANCER RESEARCH, 2019, 25 (09) : 2699 - 2707
  • [24] FGFR3 mutations in benign skin tumors
    Hafner, Christian
    Vogt, Thomas
    Hartmann, Arndt
    CELL CYCLE, 2006, 5 (23) : 2723 - 2728
  • [25] TAS-120, an irreversible FGFR inhibitor, was effective in tumors harboring FGFR mutations, refractory or resistant to ATP competitive inhibitors
    Sootome, Hiroshi
    Fujioka, Yayoi
    Miura, Akihiro
    Fujita, Hidenori
    Hirai, Hiroshi
    Utsugi, Teruhiro
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (11)
  • [26] Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion
    Kawano, Satoshi
    Kawada, Megumi ikemori
    Fukushima, Sayo
    Arai, Yasuhito
    Shibata, Tatsuhiro
    Miyano, Saori watanabe
    ANTICANCER RESEARCH, 2024, 44 (06) : 2393 - 2406
  • [27] FGFR3 mutations and FGFR3 protein overexpression in superficial bladder tumors
    Hernandez, S.
    Lopez-Knowles, E.
    Murta, C.
    Kogevinas, M.
    Lloreta, J.
    Carrato, A.
    Tradon, A.
    Serra, C.
    Malats, N.
    Real, F. X.
    EUROPEAN UROLOGY SUPPLEMENTS, 2006, 5 (14) : 808 - 808
  • [28] Phase 1 dose escalation study of FGFR4 inhibitor in combination with pembrolizumab in advanced solid tumors patients
    Xu, Jianming
    Cui, Jiuwei
    Jiang, Haiping
    Zeng, Yan
    Cong, Xiuyu
    CANCER MEDICINE, 2023, 12 (07): : 7762 - 7771
  • [29] A phase II study evaluating the safety and efficacy of ENV-101 (taladegib) in patients with advanced solid tumors harboring PTCH1 loss of function mutations
    Luke, J. J.
    Pendyala, S.
    Di Francesco, A.
    Kim, S.
    Dellamary, L.
    Humphreys, H.
    De Los Rios, M.
    Pitman, J.
    Hood, J.
    Hong, D. S.
    ANNALS OF ONCOLOGY, 2022, 33 (07) : S768 - S768
  • [30] MyTACTIC: Activity of targeted therapy in patients (pts) with advanced solid tumors harboring specific biomarkers
    Schwartzberg, Lee S.
    Spigel, David R.
    VanderWalde, Ari
    Zuniga, Richard Michael
    Hong, Jason
    Szado, Tania
    Yoo, Bongin
    Passler, Luke
    Wang, Yong
    Darbonne, Walter C.
    Daniel, Davey
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)