Hematopoietic Clonal Evolution Goes Spatial

被引：0

作者：

Austin, Rebecca ^{[1
,2
]}

Aifantis, Iannis ^{[1
,2
,3
]}

机构：

[1] NYU, Grossman Sch Med, Dept Pathol, New York, NY USA

[2] NYU, Laura & Isaac Perlmutter Canc Ctr, Grossman Sch Med, New York, NY USA

[3] NYU, Sch Med, 550 1st Ave,Smilow Res Bldg,Room 1307, New York, NY 10016 USA

来源：

BLOOD CANCER DISCOVERY | 2024年 / 5卷 / 03期

关键词：

D O I：

10.1158/2643-3230.BCD-24-0057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The spatial distribution of cells carrying clonal hematopoiesis mutations in the bone marrow and the potential role of interactions with the microenvironment are largely unknown. This study takes clonal evolution to the spatial level by describing a novel technique examining the spatial location of mutated clones in the bone marrow and the first evidence that mutated hematopoietic clones are spatially constrained and have heterogenous locations within millimeters of distance. See related article by Young et al., p. 153 (10).

引用

页码：139 / 141

页数：3

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