Revisiting liver metabolism through acetyl-CoA carboxylase inhibition

被引：1

作者：

Perez-Diaz, Armando Jesus ^{[1
]}

Nunez-Sanchez, Maria Angeles ^{[2
]}

Ramos-Molina, Bruno ^{[2
]}

机构：

[1] Univ ROMA TRE, Dept Sci, I-00146 Rome, Italy

[2] Biomed Res Inst Murcia IMIB, Obes Diabet & Metab Lab, Murcia 30120, Spain

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2024年 / 35卷 / 07期

关键词：

NASH;

D O I：

10.1016/j.tem.2024.04.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Liver-targeted acetyl-coenzyme A (CoA) carboxylase (ACC) inhibitors in metabolic dysfunction-associated steatotic liver disease (MASLD) trials reveal notable secondary effects: hypertriglyceridemia and altered glucose metabolism, paradoxically with reduced hepatic steatosis. In their study, Deja et al. explored how hepatic ACC influences metabolism using different pharmacological and genetic methods, coupled with targeted metabolomics and stable isotope-based tracing techniques.

引用

页码：563 / 565

页数：3

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