Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

被引：11
|
作者：
Wei, Li [1 ,2 ]
Kushwaha, Rajesh [3 ]
Sadhukhan, Tumpa [4 ]
Wu, Haorui [1 ]
Dao, Anyi [1 ]
Zhang, Zhishang [1 ]
Zhu, Haotu [5 ]
Gong, Qiufang [6 ]
Ru, Jiaxi [6 ]
Liang, Chao [6 ]
Zhang, Pingyu [2 ]
Banerjee, Samya [3 ]
Huang, Huaiyi [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen Campus, Shenzhen 518107, Guangdong, Peoples R China
[2] Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Guangdong, Peoples R China
[3] Indian Inst Technol BHU, Dept Chem, Varanasi 221005, Uttar Pradesh, India
[4] SRM Inst Sci & Technol, Dept Chem, Kattankulathur 603203, Tamil Nadu, India
[5] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Oncol, Shenzhen 518107, Guangdong, Peoples R China
[6] Wenzhou Med Univ, Inst Adv Res, Cixi Biomed Res Inst, Wenzhou 325035, Peoples R China
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2024年 / 67卷 / 13期
基金：
中国国家自然科学基金;
关键词：
RAMAN-SPECTROSCOPY; PHOTODYNAMIC THERAPY; RECENT PROGRESS; PHOTOSENSITIZERS; RUTHENIUM(II); IRIDIUM(III);
D O I：
10.1021/acs.jmedchem.4c00624
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The design of the dinuclear Ru(II) complex (Ru2) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. Ru2 showed impressive 700 nm light-triggered anticancer activity under normoxia and hypoxia compared with the clinically used photosensitizer Chlorin e6. The mechanistic studies showed that Ru2 induced intracellular redox imbalance and perturbed the energy metabolism and biosynthesis in A549 cancer cells. Overall, this work provides a new strategy for developing efficient metal-based complexes for anticancer phototherapy under NIR light.
引用
收藏
页码：11125 / 11137
页数：13
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