Highly efficient synthesis of enantioenriched vicinal halohydrins via Ir-catalyzed asymmetric hydrogenation using dynamic kinetic resolution

被引：0
|
作者：
He, Bin [3 ]
Chen, Gen-Qiang [4 ,5 ]
Zhang, Xumu [1 ,2 ,6 ]
机构：
[1] Southern Univ Sci & Technol, Med X Pingshan, Shenzhen 518000, Peoples R China
[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China
[3] Inst Zhejiang Univ Quzhou, Quzhou 324000, Peoples R China
[4] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China
[5] Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
[6] Chem & Chem Engn Guangdong Lab, Shantou 515031, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 72期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE SYNTHESIS; HALOGENATED KETONES; AROMATIC KETONES; RUTHENIUM; COMPLEXES; RHODIUM; LIGAND;
D O I：
10.1039/d4cc02529f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel synthetic route was developed for the construction of chiral cis-vicinal halohydrins derivatives through Ir/f-phamidol-catalysed asymmetric hydrogenation of corresponding alpha-halogenated ketones with high yields (up to 99% yield), excellent diastereoselectivities (>20 : 1 dr), enantioselectivities (up to 99% ee), and high substrate catalyst ratio (S/C = 1000).
引用
收藏
页码：9785 / 9788
页数：4
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