Recent progress in engineered extracellular vesicles and their biomedical applications

被引:3
|
作者
Mazahir, Farhan [1 ]
Yadav, Awesh K. [1 ]
机构
[1] Natl Inst Pharmaceut Educ & Res Raebareli, Dept Pharmaceut, Transit Campus,Bijnor Sisendi Rd, Lucknow 226002, India
关键词
Extracellular vesicles; Drug delivery; Cancer therapy; Neurodegenerative disorders; Vaccine production; Tuberculosis; MICROFLUIDIC DEVICE; DRUG-DELIVERY; ACOUSTIC SEPARATION; CANCER-THERAPY; EXOSOMES; PROTEINS; NANOPARTICLES; STRATEGIES; QUANTIFICATION; ENRICHMENT;
D O I
10.1016/j.lfs.2024.122747
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Aims: To present the recent update on the isolation, engineering techniques for extracellular vesicles, limitations associated with different isolation techniques, different biomedical applications, and challenges of engineered extracellular vesicles for the benefit of researchers from academic, industry, etc. Materials and methods: Peer-reviewed articles from most recognized journals were collected, and presented information was analyzed to discuss collection, chemical, electroporation, cellular, and membrane surface engineering to design extracellular vesicles for various therapeutic applications. In addition, we present the applications and limitations of techniques for the collection of extracellular vesicles. Key findings: There is a need for isolation techniques with the gold standard. However, advanced extracellular vesicle isolation techniques showed improved recovery, and purity of extracellular vesicles. Tumor therapy is a major part of the therapy section that illustrates the role of engineered extracellular vesicles in synergetic therapy such as phototherapy, theragnostic, and delivery of genetic materials. In addition, extracellular vesicles have shown their potential in the treatment of retinal disorders, neurodegenerative disease, tuberculosis, osteoporosis, inflammatory bowel disease, vaccine production, and wound healing. Significance: Engineered extracellular vesicles can deliver cargo to the specific cells, elicit an immune response and could be used for the development of the vaccines in the future. However, the progress is at the initial stage. Overall, this review will provide a comprehensive understanding and could serve as a reference for researchers in the clinical translation of engineered extracellular vesicles in different biomedical fields.
引用
收藏
页数:26
相关论文
共 50 条
  • [21] Tuning the Extracellular Vesicles Membrane through Fusion for Biomedical Applications
    Karmacharya, Mamata
    Kumar, Sumit
    Cho, Yoon-Kyoung
    JOURNAL OF FUNCTIONAL BIOMATERIALS, 2023, 14 (02)
  • [22] Engineered Extracellular Vesicles: Emerging Therapeutic Strategies for Translational Applications
    Ziegler, Jessica N.
    Tian, Changhai
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (20)
  • [23] Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications
    Yang, Chunhao
    Xue, Yunxin
    Duan, Yu
    Mao, Chun
    Wan, Mimi
    JOURNAL OF CONTROLLED RELEASE, 2024, 365 : 1089 - 1123
  • [24] Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics
    Wang, Wenshuo
    Luo, Jing
    Wang, Shutao
    ADVANCED HEALTHCARE MATERIALS, 2018, 7 (20)
  • [25] Recent progress on the design and fabrication of micromotors and their biomedical applications
    Wensen Jiang
    Liang Ma
    Xiaobin Xu
    Bio-Design and Manufacturing, 2018, (04) : 225 - 236
  • [26] Recent progress on the design and fabrication of micromotors and their biomedical applications
    Wensen Jiang
    Liang Ma
    Xiaobin Xu
    Bio-Design and Manufacturing, 2018, 1 : 225 - 236
  • [27] Recent progress in biomedical applications of persistent luminescence nanoparticles
    Wang, Jie
    Ma, Qinqin
    Wang, Yingqian
    Shen, Haijing
    Yuan, Quan
    NANOSCALE, 2017, 9 (19) : 6204 - 6218
  • [28] Recent Progress in Shape Memory Polymers for Biomedical Applications
    Hong-Mei Chen
    Lin Wang
    Shao-Bing Zhou
    Chinese Journal of Polymer Science, 2018, 36 : 905 - 917
  • [29] Recent progress of in situ formed gels for biomedical applications
    Ko, Du Young
    Shinde, Usha Pramod
    Yeon, Bora
    Jeong, Byeongmoon
    PROGRESS IN POLYMER SCIENCE, 2013, 38 (3-4) : 672 - 701
  • [30] Recent progress of antibacterial hydrogel materials for biomedical applications
    Wang, Qian
    Feng, Xing
    Xu, Hong
    Guo, Guo
    Li, Ying
    Zhang, Qilong
    JOURNAL OF MATERIALS CHEMISTRY C, 2023, 11 (38) : 12848 - 12876