Regulating epithelial-mesenchymal plasticity from 3D genome organization

被引：0
|
作者：
Pang, Qing You [1 ]
Chiu, Yi-Chia [2 ]
Huang, Ruby Yun-Ju [2 ,3 ,4 ]
机构：
[1] Natl Neurosci Inst, Neurooncol Res Lab, Singapore 308433, Singapore
[2] Natl Taiwan Univ, Coll Med, Sch Med, Taipei 10051, Taiwan
[3] Natl Taiwan Univ, Ctr Adv Comp & Imaging Biomed, Taipei 10051, Taiwan
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore 119077, Singapore
来源：
COMMUNICATIONS BIOLOGY | 2024年 / 7卷 / 01期
关键词：
SINGLE-CELL; HI-C; CHROMATIN; COHESIN; DOMAINS; EMT; DNA; TRANSITION; EXPRESSION; PRINCIPLES;
D O I：
10.1038/s42003-024-06441-w
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression. As our understanding evolves, it is clear the reversible execution of EMT arises from complex epigenomic regulation involving histone modifications and 3-dimensional (3D) genome structural changes, leading to a cascade of transcriptional events. This review summarizes current knowledge on chromatin organization in EMT, with a focus on hierarchical structures of the 3D genome and chromatin accessibility changes. A Mini Review summarizing the current understanding of epithelial-mesenchymal transition (EMT) and 3D genome organization, focusing on the role of chromatin conformation and accessibility changes during the transitional phases of EMT.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis
    Lu, Wei
    Kang, Yibin
    DEVELOPMENTAL CELL, 2019, 49 (03) : 361 - 374
  • [32] Epithelial-Mesenchymal Plasticity in Tumor Immune Evasion
    Mullins, Riley D. Z.
    Pal, Ananya
    Barrett, Thomas F.
    Neal, Molly E. Heft
    Puram, Sidharth V.
    CANCER RESEARCH, 2022, 82 (13) : 2329 - 2343
  • [33] Transcriptional census of epithelial-mesenchymal plasticity in cancer
    Cook, David P.
    Vanderhyden, Barbara C.
    SCIENCE ADVANCES, 2022, 8 (01):
  • [34] Cell memory of epithelial-mesenchymal plasticity in cancer
    Berenguer, Jordi
    Celia-Terrassa, Toni
    CURRENT OPINION IN CELL BIOLOGY, 2021, 69 : 103 - 110
  • [35] Epithelial-mesenchymal signalling regulating tooth morphogenesis
    Thesleff, I
    JOURNAL OF CELL SCIENCE, 2003, 116 (09) : 1647 - 1648
  • [36] The role of epithelial-mesenchymal transition in regulating radioresistance
    Zhou, Suna
    Zhang, Mingxin
    Zhou, Chao
    Wang, Wei
    Yang, Haihua
    Ye, Wenguang
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2020, 150
  • [37] Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family
    Katsuno, Yoko
    Derynck, Rik
    DEVELOPMENTAL CELL, 2021, 56 (06) : 726 - 746
  • [38] From 3D organization of the genome to gene expression
    Elimelech, Aviv
    Birnbaurn, Ramon Y.
    CURRENT OPINION IN SYSTEMS BIOLOGY, 2020, 22 : 22 - 31
  • [39] Erratum to: Vitamin D regulating TGF-β induced epithelial-mesenchymal transition
    Kimberly D. Fischer
    Devendra K. Agrawal
    Respiratory Research, 16
  • [40] Crotoxin Modulates Events Involved in Epithelial-Mesenchymal Transition in 3D Spheroid Model
    Kato, Ellen Emi
    Sampaio, Sandra Coccuzzo
    TOXINS, 2021, 13 (11)
12345