Regulating epithelial-mesenchymal plasticity from 3D genome organization

被引：0
|
作者：
Pang, Qing You [1 ]
Chiu, Yi-Chia [2 ]
Huang, Ruby Yun-Ju [2 ,3 ,4 ]
机构：
[1] Natl Neurosci Inst, Neurooncol Res Lab, Singapore 308433, Singapore
[2] Natl Taiwan Univ, Coll Med, Sch Med, Taipei 10051, Taiwan
[3] Natl Taiwan Univ, Ctr Adv Comp & Imaging Biomed, Taipei 10051, Taiwan
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore 119077, Singapore
来源：
COMMUNICATIONS BIOLOGY | 2024年 / 7卷 / 01期
关键词：
SINGLE-CELL; HI-C; CHROMATIN; COHESIN; DOMAINS; EMT; DNA; TRANSITION; EXPRESSION; PRINCIPLES;
D O I：
10.1038/s42003-024-06441-w
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression. As our understanding evolves, it is clear the reversible execution of EMT arises from complex epigenomic regulation involving histone modifications and 3-dimensional (3D) genome structural changes, leading to a cascade of transcriptional events. This review summarizes current knowledge on chromatin organization in EMT, with a focus on hierarchical structures of the 3D genome and chromatin accessibility changes. A Mini Review summarizing the current understanding of epithelial-mesenchymal transition (EMT) and 3D genome organization, focusing on the role of chromatin conformation and accessibility changes during the transitional phases of EMT.
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页数：11
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