Combined immunosuppressive treatment for giant cell myocarditis: a case report

被引:0
|
作者
Iebba, Filippo [1 ]
Bottari, Vera Elena [2 ]
Di Sora, Fiorella [1 ]
Mallus, Maria Teresa [2 ]
Manfredi, Rosa Maria [2 ]
Prati, Francesco [2 ]
机构
[1] San Giovanni Addolorata Hosp, Dept Clin Immunol Unit, Rome, Italy
[2] San Giovanni Addolorata Hosp, Dept Cardiol Unit, Rome, Italy
关键词
giant cell myocarditis (GCM); immunosuppressive regimen; rare disease;
D O I
10.4081/itjm.2024.1700
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Giant cell myocarditis (GCM) is a rare and often fulminant autoimmune disease. The immune-mediated pathogenesis of GCM is also supported by animal models, association with other immunological diseases and therapeutic efficacy of immunosuppressive drugs. The diagnosis of GCM is based on endomyocardial biopsy. GCM is an orphan disease. Heart transplantation is effective but up to 25% of transplanted patients experience disease recurrence. Immunosuppressive drugs have been shown to be potential therapeutic agents for GCM. In the present case report, the prescription of cyclosporine, azathioprine and prednisone resulted in a rapid and prolonged remission in support of the role of a combined immunosuppressive regimen in improving the long-term prognosis of this cardiac pathology.
引用
收藏
页数:4
相关论文
共 50 条
  • [22] Sudden Death Due to Giant Cell Myocarditis: A Case Report
    Shanmugam, Janani
    Kumar, Paranthaman Sampath
    Panicker, Vinod Kumar
    Duvooru, Prathiba
    CARDIOLOGY RESEARCH, 2015, 6 (06) : 372 - 375
  • [23] Giant-cell myocarditis - A case report and a brief review
    Latal, Jan
    Spacek, Miloslav
    Precek, Jan
    Tudos, Zbynek
    Hutyra, Martin
    Tichy, Tomas
    Taborsky, Milos
    COR ET VASA, 2018, 60 (05) : E487 - E492
  • [25] IDIOPATHIC GIANT-CELL MYOCARDITIS - CASE-REPORT
    ISAACS, RD
    ROCHE, AHG
    SMEETON, WMI
    ALI, MR
    CROXSON, MC
    NEW ZEALAND MEDICAL JOURNAL, 1986, 99 (802) : 360 - 361
  • [26] CHALLENGING GIANT CELL MYOCARDITIS: A CASE REPORT AND CLINICAL INSIGHTS
    Bin Firos, Juma
    Alsaadi, Ayman
    Naveed, Bazigh
    CHEST, 2024, 166 (04) : 3566A - 3566A
  • [27] Eosinophilic Myocarditis Progresses to Giant Cell Myocarditis Requiring Heart Transplantation: A Case Report
    Lee, Ji-Hyang
    Kim, Ah-Ram
    Lee, Sang Eun
    Song, Woo-Jung
    Kwon, Hyouk-Soo
    Kim, Tae-Bum
    Kim, Jae-Joong
    Cho, You Sook
    ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2021, 13 (02) : 353 - 355
  • [28] Clinical and Histological Response to Immunosuppressive Therapy in Giant Cell Myocarditis
    Choi, You-Jung
    Cho, Hyun-Jai
    KOREAN CIRCULATION JOURNAL, 2019, 49 (01) : 115 - 117
  • [29] A giant and rapid myocardial remodeling due to fatal giant cell myocarditis: a case report
    Zhang, Wei
    Guo, Tao
    FRONTIERS IN CARDIOVASCULAR MEDICINE, 2025, 12
  • [30] Fulminant cardiac sarcoidosis resembling giant cell myocarditis: a case report
    Jiang, Ginger Y.
    Cai, Qizhe
    Grandin, E. Wilson
    Sabe, Marwa A.
    EUROPEAN HEART JOURNAL-CASE REPORTS, 2021, 5 (03)