Early detection of pancreatic cancer in the era of precision medicine

被引：0
|
作者：
Ahmed, Taha M. [1 ]
Kawamoto, Satomi [1 ]
Lopez-Ramirez, Felipe [1 ]
Yasrab, Mohammad [1 ]
Hruban, Ralph H. [2 ]
Fishman, Elliot K. [1 ]
Chu, Linda C. [1 ]
机构：
[1] Johns Hopkins Univ Hosp, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Dept Pathol, Sch Med, Baltimore, MD USA
来源：
ABDOMINAL RADIOLOGY | 2024年 / 49卷 / 10期
关键词：
Pancreatic ductal adenocarcinoma; Cancer screening; CT; MRI; Artificial intelligence; Liquid biopsy; CIRCULATING TUMOR-CELLS; METHYLATION-BASED BIOMARKERS; DUCTAL ADENOCARCINOMA; HIGH-RISK; DNA; DIAGNOSIS; CT; PROGRESSION; SIGNATURE; EXOSOMES;
D O I：
10.1007/s00261-024-04358-w
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related mortality and it is often diagnosed at advanced stages due to non-specific clinical presentation. Disease detection at localized disease stage followed by surgical resection remains the only potentially curative treatment. In this era of precision medicine, a multifaceted approach to early detection of PDAC includes targeted screening in high-risk populations, serum biomarkers and "liquid biopsies", and artificial intelligence augmented tumor detection from radiologic examinations. In this review, we will review these emerging techniques in the early detection of PDAC.
引用
收藏
页码：3559 / 3573
页数：15
相关论文
共 50 条
  • [1] Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine
    Gwen Lomberk
    Nelson Dusetti
    Juan Iovanna
    Raul Urrutia
    Nature Communications, 10
  • [2] Targeted Therapies in Pancreatic Cancer: A New Era of Precision Medicine
    Li, Bingyu
    Zhang, Qiong
    Castaneda, Claire
    Cook, Shelly
    BIOMEDICINES, 2024, 12 (10)
  • [3] Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine
    Samarth Hegde
    Indian Journal of Surgical Oncology, 2021, 12 : 118 - 127
  • [4] Pancreatic Cancer Immuno-oncology in the Era of Precision Medicine
    Hegde, Samarth
    INDIAN JOURNAL OF SURGICAL ONCOLOGY, 2021, 12 (SUPPL 1) : 118 - 127
  • [5] Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine
    Lomberk, Gwen
    Dusetti, Nelson
    Iovanna, Juan
    Urrutia, Raul
    NATURE COMMUNICATIONS, 2019, 10 (1)
  • [6] Extracellular vesicles in pancreatic cancer: a new era in precision medicine
    Panda, Arunima
    Falasca, Marco
    Ragunath, Krish
    TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY, 2024, 9
  • [7] Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine
    Casolino, R.
    Braconi, C.
    Malleo, G.
    Paiella, S.
    Bassi, C.
    Milella, M.
    Dreyer, S. B.
    Froeling, F. E. M.
    Chang, D. K.
    Biankin, A., V
    Golan, T.
    ANNALS OF ONCOLOGY, 2021, 32 (02) : 183 - 196
  • [8] Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine
    Matsubayashi, Hiroyuki
    Kiyozumi, Yoshimi
    Ono, Hiroyuki
    JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 2025,
  • [9] Pancreatic ductal adenocarcinoma in the era of precision medicine
    Zheng-Lin, Binbin
    O'Reilly, Eileen M.
    SEMINARS IN ONCOLOGY, 2021, 48 (01) : 19 - 33
  • [10] Precision Medicine and Pancreatic Cancer
    George, Ben
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2021, 30 (04) : 693 - 708
12345