Radiation-induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report

被引：1

作者：

Takahashi-Watanabe, Manami ^{[1
]}

Fujimura, Taku ^{[1
,3
]}

Amagai, Ryo ^{[1
]}

Ohuchi, Kentaro ^{[1
]}

Yamazaki, Emi ^{[1
]}

Tamabuchi, Erika ^{[1
]}

Kuroki, Shigeru ^{[2
]}

Kambayashi, Yumi ^{[1
]}

Hashimoto, Akira ^{[1
]}

Asano, Yoshihide ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Japan

[2] Sendai Tokushukai Hosp, Dept Dermatol, Sendai, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Dermatol, 1-1 Seiryo machi,Aoba ku, Sendai, Miyagi 9808574, Japan

来源：

JOURNAL OF DERMATOLOGY | 2024年 / 51卷 / 11期

关键词：

mycosis fungoides; pembrolizumab; radiation-induced cSCC; OPEN-LABEL; T-CELLS;

D O I：

10.1111/1346-8138.17221

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation-induced cSCC with a high level of tumor-mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation-induced cSCC, even at advanced stages.

引用

页码：1500 / 1503

页数：4

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