Preparation of oat β-glucan-casein-zein nanoparticles and their encapsulation performance for α-lipoic acid

被引：0
|
作者：
Zhang, Yuanyuan [1 ]
Huang, Xin [1 ]
Zhao, Yijin [1 ]
Yan, Danyun [1 ]
Hao, Jianxiong [1 ,2 ]
Liu, Junguo [1 ,2 ]
机构：
[1] College of Food Science and Biology, Hebei University of Science and Technology, Hebei, Shijiazhuang,050000, China
[2] Hebei Innovation Centre of Functional Food Technology, Hebei, Shijiazhuang,050000, China
来源：
Jingxi Huagong/Fine Chemicals | 2023年 / 40卷 / 04期
关键词：
Chemical contamination - Chemical reactions - Controlled drug delivery - Drug products - Glycosylation - Particle size - Precipitation (chemical) - Sodium chloride - Targeted drug delivery;
D O I：
10.13550/j.jxhg.20220541
中图分类号：
学科分类号：
摘要：
LA-Zein-MC nanoparticles were prepared by anti-solvent co-precipitation with α-lipoic acid (LA) embedded in zein (Zein) as core and Maillard reaction polymer (MC) of sodium caseinate and oat β-glucan as shell, and characterized by SEM, FTIR, XRD and DSC. The LA-Zein-MC nanoparticles obtained were then tested for stability and drug release performance in simulated gastrointestinal fluid. The results showed that under these optimum preparation conditions of m(Zein)∶m(LA)=25∶1 and m(Zein)∶m(MC)=1∶2.4, the LA-Zein-MC nanoparticles prepared exhibited a particle size of 235.4 nm, Zeta potential of –32.1 mV, polydispersity index of 0.144, maximal encapsulation rate of 56.17%, and drug loading of 0.56%. Meanwhile, the LA-Zein-MC nanoparticles displayed a smooth morphology with LA embedded in the nanoparticles. Furthermore, the nanoparticles showed high NaCl stability and thermal stability, and achieved controlled drug slow release. © 2023 Fine Chemicals. All rights reserved.
引用
收藏
页码：878 / 886
相关论文
共 40 条
  • [21] a-Lipoic acid loaded hollow gold nanoparticles designed for osteoporosis treatment: preparation, characterization and in vitro evaluation
    Xi, Yanhai
    Pan, Wenming
    Liu, Yanyan
    Liu, Ji
    Xu, Guohua
    Su, Yanguo
    Chen, Daquan
    Ye, Xiaojian
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2023, 51 (01) : 131 - 138
  • [22] Encapsulation of BSA in polylactic acid-hyperbranched polyglycerol conjugate nanoparticles: preparation, characterization, and release kinetics
    Gao, Xiujun
    Zhang, Xinge
    Zhang, Xuejiao
    Cheng, Cui
    Wang, Zhen
    Li, Chaoxing
    POLYMER BULLETIN, 2010, 65 (08) : 787 - 805
  • [23] Preparation of high internal phase Pickering emulsion gels stabilized by glycyrrhizic acid-zein composite nanoparticles: Gelation mechanism and 3D printing performance
    Qiu, Chao
    Wang, Chenxi
    Li, Xiaojing
    Sang, Shangyuan
    McClements, David Julian
    Chen, Long
    Long, Jie
    Jiao, Aiquan
    Wang, Jinpeng
    Jin, Zhengyu
    FOOD HYDROCOLLOIDS, 2023, 135
  • [24] Preparation and characterization of zein-based core-shell nanoparticles for encapsulation and delivery of hydrophobic nutrient molecules: Enhancing environmental stress resistance and antioxidant activity
    Zhang, Zhiheng
    Meng, Yaxu
    Wang, Jinpeng
    Qiu, Chao
    Miao, Wenbo
    Lin, Qianzhu
    Li, Xiaojing
    Sang, Shangyuan
    McClements, David Julian
    Jiao, Aiquan
    Jin, Zhengyu
    FOOD HYDROCOLLOIDS, 2024, 148
  • [25] Microfluidic preparation of a highly active and stable catalyst by high performance of encapsulation of polyvinylpyrrolidone (PVP)-Pt nanoparticles in microcapsules
    Nam, Jin-Oh
    Kim, Jongmin
    Jin, Si Hyung
    Chung, Young-Min
    Lee, Chang-Soo
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2016, 464 : 246 - 253
  • [26] Preparation and characterization of quercetin-loaded nanoparticles based on soy protein isolate-oat (3-glucan extrudates: Interaction, structure, stability, and in vitro release properties
    Li, Jinpeng
    Li, Liang
    FOOD RESEARCH INTERNATIONAL, 2025, 202
  • [27] Curcumin encapsulation in self-assembled nanoparticles based on amphiphilic stearic acid-grafted inulin: Preparation, characterization, and functional evaluation
    Xie, Yinzhuo
    Sun, Chenxi
    Zhang, Yongrui
    Yang, Zilong
    Gao, Xiuli
    Liu, Likun
    Zhu, Wenbin
    Xue, Di
    Zou, Jiaqi
    Pei, Fangyi
    Yue, Liling
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 301
  • [28] Preparation and characterization of yeast cell wall beta-glucan encapsulated humic acid nanoparticles as an enhanced aflatoxin B1 binder
    Hamza, Zeinab
    El-Hashash, Maher
    Aly, Soher
    Hathout, Amal
    Soto, Ernesto
    Sabry, Bassem
    Ostroff, Gary
    CARBOHYDRATE POLYMERS, 2019, 203 : 185 - 192
  • [29] Poly(lactic acid)/clarithromycin with metals dioxides nanoparticles: Preparation and performance under ultraviolet irradiation
    Adil H.
    Thamer H.
    Alsayed R.
    Bufaroosha M.
    Ahmed D.S.
    Al-Mashhadani M.H.
    Hashim H.
    Husain A.A.
    Yousif E.
    Materials Science for Energy Technologies, 2024, 7 : 73 - 84
  • [30] Preparation and characterization of zein-caseinate-pectin complex nanoparticles for encapsulation of curcumin: pectin extracted by high-speed shearing from passion fruit (Passiflora edulis f. flavicarpa) peel
    Li, Xiefei
    Lin, Yupeng
    Huang, Yumeng
    Li, Xin
    An, Fengping
    Song, Hongbo
    Huang, Qun
    JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2024, 104 (11) : 6573 - 6583
1234