Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

被引：3

作者：

Alla, Deekshitha ^{[1
]}

Shah, Dhruv Jayeshkumar ^{[2
]}

Seepana, Muneesh ^{[3
]}

Salian, Rishabh Baskara ^{[4
]}

Alla, Sai Santhosha Mrudula ^{[1
]}

Krishna Mohanan, Midhun ^{[5
]}

Sabiroglu, Mert ^{[6
]}

Vegesna, Mohan Sai Sunith ^{[7
]}

Singh, Aradhya ^{[8
]}

Gupta, Srajan ^{[9
]}

Shivalingappa Rekha, Shushrutha ^{[10
]}

机构：

[1] Andhra Med Coll, Visakhapatnam, Andhra Pradesh, India

[2] Massachusetts Coll Pharm & Hlth Sci, Boston, MA USA

[3] Guntur Med Coll, Guntur, Andhra Pradesh, India

[4] Kasturba Med Coll & Hosp, Mangalore, Karnataka, India

[5] Sree Uthradom Thirunal SUT Acad Med Sci, Thiruvananthapuram, Kerala, India

[6] Koc Univ, Sch Med, Istanbul, Turkiye

[7] Jilin Univ, Changchun, Peoples R China

[8] Spartan Hlth Sci Univ, Spartan Dr,LC 12101, Vieux Fort, St Lucia

[9] SVMC, Tirupati, Andhra Pradesh, India

[10] Sri Devaraj Urs Med Coll, Kolar, Karnataka, India

来源：

GLOBAL PEDIATRIC HEALTH | 2024年 / 11卷

关键词：

proton pump inhibitors; pediatric population; GI infections; secondary infections; adverse effects; GASTROESOPHAGEAL-REFLUX DISEASE; LONG-TERM USE; OPEN-LABEL; CHILDREN; PHARMACOKINETICS; EFFICACY; RABEPRAZOLE; RISK; TOLERABILITY; ADOLESCENTS;

D O I：

10.1177/2333794X241248967

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.

引用

页数：13

共 50 条

[21] PROTON PUMP INHIBITORS AND MAJOR ADVERSE CARDIOVASCULAR OUTCOMES: A SYSTEMATIC REVIEW
Farhat, N.
Fortin, Y.
Birkett, N.
Mattison, D. R.
Krewski, D.
VALUE IN HEALTH, 2016, 19 (07) : A640 - A640
[22] The potential interaction between clopidogrel and proton pump inhibitors: a systematic review
de Aquino Lima, Joao Paulo
Brophy, James M.
BMC MEDICINE, 2010, 8
[23] Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: A systematic review
Karkos, PD
Wilson, JA
LARYNGOSCOPE, 2006, 116 (01): : 144 - 148
[24] A SYSTEMATIC REVIEW OF THE POTENTIAL INTERACTION BETWEEN CLOPIDOGREL AND PROTON PUMP INHIBITORS
Lima, J. de Aquino
Brophy, J.
CANADIAN JOURNAL OF CARDIOLOGY, 2010, 26 : 28D - 28D
[25] The potential interaction between clopidogrel and proton pump inhibitors: a systematic review
Joao Paulo de Aquino Lima
James M Brophy
BMC Medicine, 8
[26] Systematic review of proton pump inhibitors for the acute treatment of reflux oesophagitis
Edwards, SJ
Lind, T
Lundell, L
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2001, 15 (11) : 1729 - 1736
[27] Approaches to Deprescribing Proton Pump Inhibitors in Clinical Practice: A Systematic Review
Rossi, Andrea
Perrella, Lara
Scotti, Stefano
Olmastroni, Elena
Galimberti, Federica
Ardoino, Ilaria
Orlando, Valentina
Menditto, Enrica
Franchi, Carlotta
Casula, Manuela
JOURNAL OF CLINICAL MEDICINE, 2024, 13 (20)
[28] Use of Proton Pump Inhibitors in the Management of Gastroesophageal Varices: A Systematic Review
Lo, Elaine A. G.
Wilby, Kyle J.
Ensom, Mary H. H.
ANNALS OF PHARMACOTHERAPY, 2015, 49 (02) : 207 - 219
[29] A systematic review of the role of proton pump inhibitors for symptoms of laryngopharyngeal reflux
Sen, P
Georgalas, C
Bhattacharyya, AK
CLINICAL OTOLARYNGOLOGY, 2006, 31 (01): : 20 - 24
[30] Proton Pump Inhibitors for the Treatment of Laryngopharyngeal Reflux. A Systematic Review
Spantideas, Nikolaos
Drosou, Eirini
Bougea, Anastasia
AlAbdulwahed, Reem
JOURNAL OF VOICE, 2020, 34 (06) : 918 - 929

← 1 2 3 4 5 →