Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

被引：3

作者：

Alla, Deekshitha ^{[1
]}

Shah, Dhruv Jayeshkumar ^{[2
]}

Seepana, Muneesh ^{[3
]}

Salian, Rishabh Baskara ^{[4
]}

Alla, Sai Santhosha Mrudula ^{[1
]}

Krishna Mohanan, Midhun ^{[5
]}

Sabiroglu, Mert ^{[6
]}

Vegesna, Mohan Sai Sunith ^{[7
]}

Singh, Aradhya ^{[8
]}

Gupta, Srajan ^{[9
]}

Shivalingappa Rekha, Shushrutha ^{[10
]}

机构：

[1] Andhra Med Coll, Visakhapatnam, Andhra Pradesh, India

[2] Massachusetts Coll Pharm & Hlth Sci, Boston, MA USA

[3] Guntur Med Coll, Guntur, Andhra Pradesh, India

[4] Kasturba Med Coll & Hosp, Mangalore, Karnataka, India

[5] Sree Uthradom Thirunal SUT Acad Med Sci, Thiruvananthapuram, Kerala, India

[6] Koc Univ, Sch Med, Istanbul, Turkiye

[7] Jilin Univ, Changchun, Peoples R China

[8] Spartan Hlth Sci Univ, Spartan Dr,LC 12101, Vieux Fort, St Lucia

[9] SVMC, Tirupati, Andhra Pradesh, India

[10] Sri Devaraj Urs Med Coll, Kolar, Karnataka, India

来源：

GLOBAL PEDIATRIC HEALTH | 2024年 / 11卷

关键词：

proton pump inhibitors; pediatric population; GI infections; secondary infections; adverse effects; GASTROESOPHAGEAL-REFLUX DISEASE; LONG-TERM USE; OPEN-LABEL; CHILDREN; PHARMACOKINETICS; EFFICACY; RABEPRAZOLE; RISK; TOLERABILITY; ADOLESCENTS;

D O I：

10.1177/2333794X241248967

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.

引用

页数：13

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