Recent Advances in Research on Active Compounds Against Hepatic Fibrosis

被引:1
|
作者
Liu, Chuang [1 ]
Li, Siqi [1 ]
Zhang, Changhao [1 ]
Jin, Cheng-Hua [1 ,2 ]
机构
[1] Yanbian Univ, Coll Pharm, Key Lab Nat Resources Changbai Mt, Minist Educ,Mol Med Res Ctr, Yanji 133002, Jilin, Peoples R China
[2] Yanbian Univ, Coll Integrat Sci, Interdisciplinary Biol Funct Mol, Yanji 133002, Jilin, Peoples R China
基金
中国国家自然科学基金;
关键词
Liver fibrosis; chronic liver diseases; cirrhosis; SAR; HSC; collagen I; INDUCED LIVER FIBROSIS; KAPPA-B-ALPHA; GYNOSTEMMA-PENTAPHYLLUM SAPONINS; DAMMARANE-TYPE TRITERPENES; CARBON-TETRACHLORIDE; SIGNALING PATHWAY; BIOLOGICAL EVALUATION; STELLATE CELLS; IN-VITRO; ANTIMICROBIAL EVALUATION;
D O I
10.2174/0929867331666230727102016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Almost all chronic liver diseases cause fibrosis, which can lead to cirrhosis and eventually liver cancer. Liver fibrosis is now considered to be a reversible pathophysiological process and suppression of fibrosis is necessary to prevent liver cancer. At present, no specific drugs have been found that have hepatic anti-fibrotic activity.Objective: The research progress of anti-hepatic fibrosis compounds in recent ten years was reviewed to provide a reference for the design and development of anti-hepatic fibrosis drugs.Methods: According to the structure of the compounds, they are divided into monocyclic compounds, fused-heterocyclic compounds, and acyclic compounds.Results: In this article, the natural products and synthetic compounds with anti-fibrotic activity in recent ten years were reviewed, with emphasis on their pharmacological activity and structure-activity relationship (SAR).Conclusion: Most of these compounds are natural active products and their derivatives, and there are few researches on synthetic compounds and SAR studies on natural product.
引用
收藏
页码:2571 / 2628
页数:58
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