Ligand control of regioselectivity in palladium-catalyzed heteroannulation reactions of 1,3-Dienes

Olefin carbofunctionalization reactions are indispensable tools for constructing diverse, functionalized scaffolds from simple starting materials. However, achieving precise control over regioselectivity in intermolecular reactions remains a formidable challenge. Here, we demonstrate that using PAd2nBu as a ligand enables regioselective heteroannulation of o-bromoanilines with branched 1,3-dienes through ligand control. This approach provides regiodivergent access to 3-substituted indolines, showcasing excellent regioselectivity and reactivity across a range of functionalized substrates. To gain further insights into the origin of selectivity control, we employ a data-driven strategy, developing a linear regression model using calculated parameters for phosphorus ligands. This model identifies four key parameters governing regioselectivity in this transformation, paving the way for future methodology development. Additionally, density functional theory calculations elucidate key selectivity-determining transition structures along the reaction pathway, corroborating our experimental observations and establishing a solid foundation for future advancements in regioselective olefin difunctionalization reactions. Olefins are common starting points for syntheses as they are widely available and can often be functionalized twice in one step, but controlling the regioselectivity of these difunctionalizations remains a challenge, even in relatively well-understood transformations. Here, the authors effect regioselective heteroannulation of o-bromoanilines with branched 1,3- dienes via ligand control, using palladium catalysis.