For the two types of heat sources, open heat source and closed heat source, two heat source temperatures of 423.15 K and 463.15 K were selected, and the none-azeotropic mixed working fluid subcritical organic Rankine cycle (ORC) thermodynamic and thermal economic characteristics were used for simulation analysis. Four thermo-economic indexes are selected, such as levelized energy cost (LEC), area per unit of net power (APR), cost per unit of time (Z) and net power index (NPI). The results show that four thermo-economic indexes are consistent and show same parabolic change trend. With the increase of fluids critical temperature, thermo-economic indexes change regularly. The working fluids selected by the thermodynamic screening criteria have higher thermo-economic performance, indicating that the thermodynamic screening criteria also show high applicability in thermo-economic analysis. © 2021, Editorial Board of CIESC Journal. All right reserved.