Impact of Fenfluramine on drop seizure frequency in adults or dose- capped patients with Lennox-Gastaut Syndrome: comparative analysis of clinical trial data

被引:0
|
作者
Scheffer, I. E. [1 ]
Ceulemans, B. [2 ]
Sullivan, J. [3 ]
Nickels, K. C. [4 ]
Lagae, L. [5 ,6 ]
Guerrini, R. [7 ,8 ]
Zuberi, S. M. [9 ]
Nabbout, R. [10 ]
Riney, K. [11 ,12 ]
Polega, S. [13 ]
Lothe, A. [14 ]
Davis, R. [15 ]
Gil-Nagel, A. [16 ]
机构
[1] Univ Melbourne, Austin & Royal Childrens Hosp, Melbourne, Australia
[2] Antwerp Univ Hosp, Dept Paediat Neurol, Antwerp, Belgium
[3] Univ Calif San Francisco, Benioff Childrens Hosp, Weill Inst Neurosci, San Francisco, CA USA
[4] Mayo Clin, Dept Neurol, Rochester, MN USA
[5] European Reference Network EpiCARE, Leuven, Belgium
[6] Univ Leuven, Dept Paediat Neurol, Leuven, Belgium
[7] Univ Florence, Anna Meyer Childrens Hosp, Pediat Neurol & Neurogenet Unit, Florence, Italy
[8] IRCCS Fdn Stella Maris, Pisa, Italy
[9] Royal Hosp Children, Paediat Neurosci Res Grp, Glasgow, Scotland
[10] Univ Paris Cite, Hop Univ Necker Enfants Malad, APHP,EPICARE, Reference Ctr Rare Epilepsies,Inst Imagine, Paris, France
[11] Queensland Childrens Hosp, Neurosci Unit, South Brisbane, Australia
[12] Univ Queensland, Sch Clin Med, St Lucia, Australia
[13] Zogenix Inc, Emeryville, CA USA
[14] Zogenix Int LTD, Maidenhead, England
[15] Neurol & Epilepsy Res Ctr, Orlando, FL USA
[16] Hosp Ruber Int, Madrid, Spain
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
735
引用
收藏
页码:8 / 8
页数:1
相关论文
共 37 条
  • [21] Cannabidiol (CBD) significantly reduces drop seizure frequency in Lennox-Gastaut syndrome (LGS): results of a dose-ranging, multi-center, randomized, double-blind, placebo-controlled trial (GWPCARE3)
    Patel, Anup
    Devinsky, Orrin
    Cross, J. Helen
    Villanueva, Vicente
    Wirrell, Elaine
    VanLandingham, Kevan
    Roberts, Claire
    Checketts, Daniel
    Zuberi, Sameer
    NEUROLOGY, 2017, 89 (08) : E100 - E100
  • [22] Seizure Outcomes With Cannabidiol (CBD) in Pediatric Versus Adult Patients With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS): Subgroup Analysis of BECOME, a Caregiver Survey
    Saurer, T.
    Berg, A.
    Dixon-Salazar, T.
    Meskis, M.
    Danese, S.
    Le, N.
    Perry, M.
    ANNALS OF NEUROLOGY, 2023, 94 : S54 - S54
  • [23] Lennox-Gastaut syndrome in adulthood: Long-term clinical follow-up of 38 patients and analysis of their recorded seizures
    Vignoli, Aglaia
    Oggioni, Gaia
    De Maria, Giovanni
    Peron, Angela
    Savini, Miriam Nella
    Zambrelli, Elena
    Chiesa, Valentina
    La Briola, Francesca
    Turner, Katherine
    Canevini, Maria Paola
    EPILEPSY & BEHAVIOR, 2017, 77 : 73 - 78
  • [24] Seizure outcomes with cannabidiol (CBD) in pediatric versus adult patients with Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS): Subgroup analysis of become, a caregiver survey
    Saurer, Timothy B.
    Dixon-Salazar, Tracy
    Berg, Anne T.
    Meskis, Mary Anne
    Danese, Sherry R.
    Le, Ngoc Minh D.
    Perry, M. Scott
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2023, 455
  • [25] QUALITY OF LIFE IN PATIENTS WITH DRAVET SYNDROME OR LENNOX GASTAUT SYNDROME IN THE UK: HIGHER SEIZURE FREQUENCY HAS A SUBSTANTIAL NEGATIVE IMPACT ON QUALITY OF LIFE
    Radu, X.
    Damera, V
    Martin, M.
    Simontacchi, K.
    Holland, R.
    VALUE IN HEALTH, 2019, 22 : S346 - S346
  • [26] CANNABIDIOL (CBD) SIGNIFICANTLY REDUCES DROP AND TOTAL SEIZURE FREQUENCY IN LENNOX-GASTAUT SYNDROME (LGS): RESULTS OF A DOSE-RANGING, MULTI-CENTRE, RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL (GWPCARE3)
    Zuberi, S.
    Devinsky, O.
    Patel, A.
    Cross, J. H.
    Villanueva, V.
    Wirrell, E. C.
    Roberts, C.
    Checketts, D.
    van Landingham, K.
    EPILEPSIA, 2017, 58 : S13 - S14
  • [27] Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial
    Ohtsuka, Yoko
    Yoshinaga, Harumi
    Shirasaka, Yukiyoshi
    Takayama, Rumiko
    Takano, Hiroki
    Iyoda, Kuniaki
    EPILEPSY RESEARCH, 2016, 121 : 1 - 7
  • [28] Interim data from the ENDYMION 1 trial investigating the long-term treatment effects of soticlestat in patients with Dravet syndrome or Lennox-Gastaut syndrome
    Asgharnejad, M.
    Yao, Y.
    Mitra, P.
    Murthy, V.
    EPILEPSIA, 2024, 65 : 164 - 164
  • [29] Clobazam-treated patients with Lennox-Gastaut syndrome experienced fewer seizure-related injuries than placebo patients during trial OV-1012
    Isojarvi, Jouko
    Lee, Deborah
    Peng, Guangbin
    Sperling, Michael R.
    EPILEPSIA, 2016, 57 (06) : E113 - E116
  • [30] Seizure-free days as a novel outcome in patients with Lennox-Gastaut syndrome: Post hoc analysis of patients receiving cannabidiol in two randomized controlled trials
    Auvin, Stephane
    Nortvedt, Charlotte
    Fuller, Douglas S.
    Sahebkar, Farhad
    EPILEPSIA, 2023, 64 (07) : 1812 - 1820