Advances in fluorescence sensing enabled by lanthanide-doped upconversion nanophosphors

Lanthanide-doped upconversion nanoparticles (UCNPs), characterized by converting low-energy excitation to high-energy emission, have attracted considerable interest due to their inherent advantages of large anti-Stokes shifts, sharp and narrow multicolor emissions, negligible autofluorescence background interference, and excellent chemical- and photo-stability. These features make them promising luminophores for sensing applications. In this review, we give a comprehensive overview of lanthanide-doped upconversion nanophosphors including the fundamental principle for the construction of UCNPs with efficient upconversion luminescence (UCL), followed by state-of-the-art strategies for the synthesis and surface modification of UCNPs, and finally describing current advances in the sensing application of upconversion-based probes for the quantitative analysis of various analytes including pH, ions, molecules, bacteria, reactive species, temperature, and pressure. In addition, emerging sensing applications like photodetection, velocimetry, electromagnetic field, and voltage sensing are highlighted. © 2021 Elsevier B.V.