GnRH-a-based fertility-sparing treatment of atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EC) patients: a multicenter, open-label, randomized designed clinical trial protocol

被引:1
|
作者
Qian Liu [1 ]
Huimei Zhou [1 ]
Mei Yu [1 ]
Dongyan Cao [1 ]
Jiaxin Yang [1 ]
机构
[1] Peking Union Medical College Hospital,Department of Obstetrics and Gynecology
[2] Peking Union Medical College,undefined
[3] Chinese Academy of Medical Sciences,undefined
[4] National Clinical Research Center for Obstetric and Gynecologic Diseases,undefined
关键词
Endometrial neoplasms; Endometrial hyperplasia; Fertility preservation; Progestins; Gonadotropin-releasing hormone; Pregnancy outcome;
D O I
10.1186/s13063-024-08414-0
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 26 条
  • [21] Safety and Efficacy of the mTOR Inhibitor, Vistusertib, Combined With Anastrozole in Patients With Hormone Receptor-Positive Recurrent or Metastatic Endometrial Cancer The VICTORIA Multicenter, Open-label, Phase 1/2 Randomized Clinical Trial
    Heudel, Pierre
    Frenel, Jean-Sebastien
    Dalban, Cecile
    Bazan, Fernando
    Joly, Florence
    Arnaud, Antoine
    Abdeddaim, Cyril
    Chevalier-Place, Annick
    Augereau, Paule
    Pautier, Patricia
    Chakiba, Camille
    You, Benoit
    Lancry-Lecomte, Laurence
    Garin, Gwenaelle
    Marcel, Virginie
    Diaz, Jean Jacques
    Treilleux, Isabelle
    Perol, David
    Fabbro, Michel
    Ray-Coquard, Isabelle
    JAMA ONCOLOGY, 2022, 8 (07) : 1001 - 1009
  • [22] Clinical outcomes of levonorgestrel-releasing intrauterine device present during controlled ovarian stimulation in patients with early stage endometrioid adenocarcinoma and atypical endometrial hyperplasia after fertility-sparing treatments: 10-year experience in one tertiary hospital in China
    Yin, Jie
    Li, Yan
    Wang, Hanbi
    Wang, Wei
    Gu, Yu
    Jin, Ying
    Deng, Chengyan
    Pan, Lingya
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2023, 280 : 83 - 88
  • [23] Comparison of the effect of oral megestrol acetate with or without levonorgestrel-intrauterine system on fertility-preserving treatment in patients with early-stage endometrial cancer: a prospective, open-label, randomized controlled phase II trial (ClinicalTrials.gov NCT03241914)
    Xu, Zhiying
    Yang, Bingyi
    Guan, Jun
    Shan, Weiwei
    Liao, Jiongbo
    Shao, Wenyu
    Chen, Xiaojun
    JOURNAL OF GYNECOLOGIC ONCOLOGY, 2023, 34 (01)
  • [24] Induction of Cure in Early Arthritis (I CEA): study protocol for an investigator-initiated randomized single-blind clinical trial with open-label extension to compare three treatment strategies in patients with newly diagnosed undifferentiated arthritis
    Bergstra, S. A.
    van Ouwerkerk, L.
    Nevins, I. S.
    van der Pol, J. A.
    Helmich, G. S.
    Hest, I.
    van Veen, A.
    Bos, R.
    Goekoop-Ruiterman, Y. P. M.
    Vonkeman, H. E.
    Bijsterbosch, J.
    de Jong, P. H. P.
    Guler-Yuksel, M.
    Bohringer, S.
    Huizinga, T. W. J.
    van Gaalen, F. A.
    TRIALS, 2024, 25 (01)
  • [25] Delamanid, linezolid, levofloxacin, and pyrazinamide for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (Treatment Shortening of MDR-TB Using Existing and New Drugs, MDR-END): study protocol for a phase II/III, multicenter, randomized, open-label clinical trial
    Myungsun Lee
    Jeongha Mok
    Deog Kyeom Kim
    Tae Sun Shim
    Won-Jung Koh
    Doosoo Jeon
    Taehoon Lee
    Seung Heon Lee
    Ju Sang Kim
    Jae Seuk Park
    Ji Yeon Lee
    Song Yee Kim
    Jae Ho Lee
    Kyung-Wook Jo
    Byung Woo Jhun
    Young Ae Kang
    Joong Hyun Ahn
    Chang-Ki Kim
    Soyoun Shin
    Taeksun Song
    Sung Jae Shin
    Young Ran Kim
    Heejung Ahn
    Seokyung Hahn
    Ho Jeong Won
    Ji Yeon Jang
    Sang Nae Cho
    Jae-Joon Yim
    Trials, 20
  • [26] Delamanid, linezolid, levofloxacin, and pyrazinamide for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (Treatment Shortening of MDR-TB Using Existing and New Drugs, MDR-END): study protocol for a phase II/III, multicenter, randomized, open-label clinical trial
    Lee, Myungsun
    Mok, Jeongha
    Kim, Deog Kyeom
    Shim, Tae Sun
    Koh, Won-Jung
    Jeon, Doosoo
    Lee, Taehoon
    Lee, Seung Heon
    Kim, Ju Sang
    Park, Jae Seuk
    Lee, Ji Yeon
    Kim, Song Yee
    Lee, Jae Ho
    Jo, Kyung-Wook
    Jhun, Byung Woo
    Kang, Young Ae
    Ahn, Joong Hyun
    Kim, Chang-Ki
    Shin, Soyoun
    Song, Taeksun
    Shin, Sung Jae
    Kim, Young Ran
    Ahn, Heejung
    Hahn, Seokyung
    Won, Ho Jeong
    Jang, Ji Yeon
    Cho, Sang Nae
    Yim, Jae-Joon
    TRIALS, 2019, 20 (1)