Exploring novel perspectives on eosinophilic inflammation in severe asthma

被引：1
|
作者：
Candia, Claudio [1 ]
Ambrosino, Pasquale [2 ]
D'Anna, Silvestro E. [2 ]
Motta, Andrea [3 ]
Maniscalco, Mauro [1 ,2 ]
机构：
[1] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy
[2] Ist Clin Scientif Maugeri IRCCS, Telese Terme Inst, Pulm Rehabil Unit, I-82037 Telese Terme, Italy
[3] CNR, Inst Biomol Chem, I-80078 Pozzuoli, Italy
来源：
BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 08期
关键词：
biomarkers; eosinophilic inflammation; eosinophil subtypes; outcome; rehabilitation; severe asthma;
D O I：
10.2217/bmm-2023-0801
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62L(low) inflammatory eosinophils (iEos) and identified an intriguing correlation between such iEos and asthma control scores. Moreover, CD62L(low) iEos were reduced after treatment with the anti-IL-5 monoclonal antibody mepolizumab. In the future, we believe that eosinophil subtypes could represent a useful biomarker in severe eosinophilic asthma, helping clinicians characterize patient endotypes and monitoring the response to biological drugs.
引用
收藏
页码：357 / 361
页数：5
相关论文
共 50 条
  • [21] Molecular markers of type 2 airway inflammation are similar between eosinophilic severe asthma and eosinophilic COPD
    Fricker, Michael
    McDonald, Vanessa M.
    Winter, Natasha A.
    Baines, Katherine J.
    Wark, Peter A. B.
    Simpson, Jodie L.
    Gibson, Peter G.
    ALLERGY, 2021, 76 (07) : 2079 - 2089
  • [22] Biomarkers for severe eosinophilic asthma
    Yancey, Steven W.
    Keene, Oliver N.
    Albers, Frank C.
    Ortega, Hector
    Bates, Stewart
    Bleecker, Eugene R.
    Pavord, Ian
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 140 (06) : 1509 - 1518
  • [23] Severe eosinophilic asthma and mepolizumab
    Walsh, Garry M.
    LANCET RESPIRATORY MEDICINE, 2016, 4 (07): : 528 - 529
  • [24] Eosinophilic Inflammation Is Associated With A 25KDa Nitrosylated Protein In Severe Asthma
    Yamamoto, M.
    Tochino, Y.
    Wenzel, S. E.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [25] MEPOLIZUMAB IN SEVERE EOSINOPHILIC ASTHMA
    Shahzad, Q.
    Zaheer, M.
    CHEST, 2020, 157 (06) : 275A - 275A
  • [26] Severe refractory eosinophilic asthma
    Jäger-Becker D.
    MMW - Fortschritte der Medizin, 2016, 158 (3) : 67 - 67
  • [27] Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation
    Sousa, A. R.
    Marshall, R. P.
    Warnock, L. C.
    Bolton, S.
    Hastie, A.
    Symon, F.
    Hargadon, B.
    Marshall, H.
    Richardson, M.
    Brightling, C. E.
    Haldar, P.
    Milone, R.
    Chalk, P.
    Williamson, R.
    Panettieri, R., Jr.
    Knowles, R.
    Bleecker, E. R.
    Wardlaw, A. J.
    CLINICAL AND EXPERIMENTAL ALLERGY, 2017, 47 (07): : 890 - 899
  • [28] EOSINOPHILIC AIRWAY INFLAMMATION IS ASSOCIATED WITH FEV1 DECLINE IN SEVERE ASTHMA
    Agbetile, J.
    Desai, D.
    Hargadon, B.
    Bradding, P.
    Wardlaw, A. J.
    Pavord, I. D.
    Green, R. H.
    Brightling, C. E.
    Siddiqui, S.
    THORAX, 2010, 65 : A61 - A61
  • [29] Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma
    Itakura, Koji
    Fujino, Naoya
    Kamide, Yosuke
    Saito, Ikuo
    Yamada, Mitsuhiro
    Okutomo, Koji
    Tsukita, Yoko
    Saito, Takuya
    Ichikawa, Tomohiro
    Numakura, Tadahisa
    Kyogoku, Yorihiko
    Aizawa, Hiroyuki
    Ono, Yoshinao
    Matsumoto, Shuichiro
    Hussell, Tracy
    Taniguchi, Masami
    Ichinose, Masakazu
    Sugiura, Hisatoshi
    ALLERGOLOGY INTERNATIONAL, 2022, 71 (03) : 383 - 394
  • [30] Eosinophilic bioactivities in severe asthma
    Carr, Tara F.
    Berdnikovs, Sergejs
    Simon, Hans-Uwe
    Bochner, Bruce S.
    Rosenwasser, Lanny J.
    WORLD ALLERGY ORGANIZATION JOURNAL, 2016, 9
12345