Exploring novel perspectives on eosinophilic inflammation in severe asthma

被引：1
|
作者：
Candia, Claudio [1 ]
Ambrosino, Pasquale [2 ]
D'Anna, Silvestro E. [2 ]
Motta, Andrea [3 ]
Maniscalco, Mauro [1 ,2 ]
机构：
[1] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy
[2] Ist Clin Scientif Maugeri IRCCS, Telese Terme Inst, Pulm Rehabil Unit, I-82037 Telese Terme, Italy
[3] CNR, Inst Biomol Chem, I-80078 Pozzuoli, Italy
来源：
BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 08期
关键词：
biomarkers; eosinophilic inflammation; eosinophil subtypes; outcome; rehabilitation; severe asthma;
D O I：
10.2217/bmm-2023-0801
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62L(low) inflammatory eosinophils (iEos) and identified an intriguing correlation between such iEos and asthma control scores. Moreover, CD62L(low) iEos were reduced after treatment with the anti-IL-5 monoclonal antibody mepolizumab. In the future, we believe that eosinophil subtypes could represent a useful biomarker in severe eosinophilic asthma, helping clinicians characterize patient endotypes and monitoring the response to biological drugs.
引用
收藏
页码：357 / 361
页数：5
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