A mechanistic review on growing multiple therapeutic applications of lutein and its global market research

被引:6
|
作者
Akkewar, Ashish Sunil [1 ]
Mishra, K. M. Abha [1 ]
Kamble, Mahesh Gopichand [1 ]
Kumar, Sanjay [1 ]
Dey, Juhi [1 ]
Sethi, Kalyan Kumar [1 ,2 ]
机构
[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, Gauhati, India
[2] Natl Inst Pharmaceut Educ & Res Guwahati, Dept Med Chem, Gauhati 781101, Assam, India
关键词
age-related macular degeneration; antioxidant; biosynthesis; carotenoids; clinical trials; lutein; market research; TAGETES-ERECTA L; MACULAR PIGMENT; ANTIOXIDANT ACTIVITY; CAROTENOID LUTEIN; OXIDATIVE STRESS; PLASMA CAROTENOIDS; PROTECTIVE ROLE; IN-VITRO; ZEAXANTHIN SUPPLEMENTATION; ULTRAVIOLET-RADIATION;
D O I
10.1002/ptr.8197
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Lutein is a naturally occurring carotenoid synthesized by plants and algae that has a beneficial effect on several biological processes and associated ailments. Its immediate application is in ophthalmology, where it significantly lowers the incidences of age-related macular degeneration (AMD). It also has anti-inflammatory action, treatment of diabetic retinopathy, and cataracts, and enhancement of visual contrast. To critically assess lutein biosynthesis, therapeutic applicability, and market research literature. We have discussed its theoretical frameworks, experimental evidence, limitations, as well as clinical trial results, and future research prospects. The literature for this review article was mined and compiled by collecting and analyzing articles from several databases, including ScienceDirect, Google Scholar, PubMed, Wiley Online Library, Patentscope, and published until March 30, 2022. Patent publications were identified using the search terms like IC:(C07C67/56) AND EN_AB:(lutein) OR EN_TI:(lutein) OR EN_AB:(extraction) OR EN_TI:(process). According to the literature, lutein is an essential nutrient given that it cannot be synthesized in the human body and acts as an antioxidant, affecting AMD, diabetic retinopathy, Rheumatic diseases, inflammation, and cancer. Due to inadequate production and laborious extraction, lutein is expensive despite its high demand and applicability. Market research predicts a 6.3% compound annual growth rate for lutein by 2032. Optimizing lutein extraction for high yield and purity is necessary. Lutein has proven applicability in various ailments as well as cosmetics that can be developed as a candidate drug for various diseases discussed in the review. Global lutein production and its therapeutic applications. image
引用
收藏
页码:3190 / 3217
页数:28
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