A pH responsive tannic acid/quaternized carboxymethyl chitosan/oxidized sodium alginate hydrogels for accelerated diabetic wound healing and real-time monitoring

被引：19
|
作者：
Yang, Zhifei [1 ]
Wang, Chen [2 ]
Zhang, Zhiyuan [2 ]
Yu, Fangzheng [2 ]
Wang, Yu [2 ]
Ding, Jianqiang [2 ]
Zhao, Zheng [1 ,2 ]
Liu, Yichao [3 ]
机构：
[1] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China
[2] Wuhan Univ Technol, Hainan Inst, Sanya 572000, Peoples R China
[3] Wuhan Univ, Zhongnan Hosp, Ctr Evidence Based & Translat Med, Wuhan 430070, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 264卷
基金：
中国国家自然科学基金;
关键词：
Quaternized carboxymethyl chitosan; Oxidized sodium alginate; Tannic acid; Carbon quantum dots; Real-time monitoring; CARBON DOTS; ANTIBACTERIAL; CHITOSAN; OXIDATION; NITROGEN;
D O I：
10.1016/j.ijbiomac.2024.130741
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Treatment of diabetic wounds is a major clinical issue. Diabetic wound dressings have higher requirements for anti-oxidant, antibacterial and wound monitoring properties compared to conventional wound dressings. In this study, a novel tannic acid (TA)/quaternized carboxymethyl chitosan (QCMCS)/oxidized sodium alginate (OSA) @carbon quantum dots (CQD) (TA/QCMCS/OSA@CQD) hydrogels for promoting diabetic wound healing and real -time monitoring have been developed. The TA/QCMCS/OSA@CQD hydrogels exhibited excellent selfhealing, antibacterial and antioxidant properties. Besides, these hydrogels possessed good biocompatibility and effective hemostasis in a mouse liver injury model and significantly facilitated the healing process in a diabetic wound model. In addition, these hydrogels can reliable and timely measure the diabetic wound pH information by collecting image signals of hydrogels to monitor the healing status. Therefore, the pH responsive TA/QCMCS/OSA@CQD hydrogels could be utilized as wound dressing for promoting diabetic wound healing and real -time monitoring.
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页数：13
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