A hybrid pathway for self-sustained luminescence

被引：1

作者：

Palkina, Kseniia A. ^{[1
,2
]}

Karataeva, Tatiana A. ^{[1
,2
]}

Perfilov, Maxim M. ^{[1
,2
]}

Fakhranurova, Liliia I. ^{[1
,2
]}

Markina, Nadezhda M. ^{[1
,2
]}

Somermeyer, Louisa Gonzalez ^{[3
]}

Garcia-Perez, Elena ^{[4
]}

Vazquez-Vilar, Marta ^{[4
]}

Rodriguez-Rodriguez, Marta ^{[4
]}

Vazquez-Vilriales, Victor ^{[4
]}

Shakhova, Ekaterina S. ^{[1
,2
]}

Mitiouchkina, Tatiana ^{[1
,2
]}

Belozerova, Olga A. ^{[2
]}

Kovalchuk, Sergey I. ^{[2
]}

Alekberova, Anna ^{[1
,2
]}

Malyshevskaia, Alena K. ^{[1
,2
]}

Bugaeva, Evgenia N. ^{[1
]}

Guglya, Elena B. ^{[2
,5
]}

Balakireva, Anastasia ^{[1
,2
]}

Sytov, Nikita ^{[2
]}

Bezlikhotnova, Anastasia ^{[1
]}

Boldyreva, Daria I. ^{[6
]}

Babenko, Vladislav V. ^{[6
]}

Kondrashov, Fyodor A. ^{[7
]}

Choob, Vladimir V. ^{[8
]}

Orzaez, Diego ^{[4
]}

Yampolsky, Ilia V. ^{[1
,2
,5
,9
]}

Mishin, Alexander S. ^{[1
,2
]}

Sarkisyan, Karen S. ^{[1
,2
,9
,10
,11
,12
]}

机构：

[1] Planta LLC, Moscow 121205, Russia

[2] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

[3] IST Austria, A-3400 Klosterneuburg, Austria

[4] Univ Politecn Valencia, CSIC, Inst Biol Mol & Celular Plantas IBMCP, Valencia 46022, Spain

[5] Pirogov Russian Natl Res Med Univ, Ostrovityanova 1, Moscow 117997, Russia

[6] Fed Med Biol Agcy, Lopukhin Fed Res & Clin Ctr Phys Chem Med, Moscow, Russia

[7] Grad Univ, Okinawa Inst Sci & Technol, Onna, Okinawa 9040412, Japan

[8] Lomonosov Moscow State Univ, Bot Garden, Vorobievy Gory 1 b 12, Moscow 117234, Russia

[9] Light Bio Inc, Ketchum, ID 83340 USA

[10] Synthet Biol Grp, MRC Lab Med Sci, London, England

[11] Imperial Coll London, Inst Clin Sci, Fac Med, London, England

[12] Imperial Coll London, Imperial Coll Ctr Synthet Biol, London, England

来源：

SCIENCE ADVANCES | 2024年 / 10卷 / 10期

关键词：

CELL-SUSPENSION CULTURES; III POLYKETIDE SYNTHASES; CHALCONE SYNTHASE; EXPRESSION SYSTEM; BIOSYNTHESIS; PROTEIN;

D O I：

10.1126/sciadv.adk1992

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The fungal bioluminescence pathway can be reconstituted in other organisms allowing luminescence imaging without exogenously supplied substrate. The pathway starts from hispidin biosynthesis-a step catalyzed by a large fungal polyketide synthase that requires a posttranslational modification for activity. Here, we report identification of alternative compact hispidin synthases encoded by a phylogenetically diverse group of plants. A hybrid bioluminescence pathway that combines plant and fungal genes is more compact, not dependent on availability of machinery for posttranslational modifications, and confers autonomous bioluminescence in yeast, mammalian, and plant hosts. The compact size of plant hispidin synthases enables additional modes of delivery of autoluminescence, such as delivery with viral vectors.

引用

页数：8

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