TBHP-Mediated Hydroxyperfluoroalkylation of Alkenes with Perfluoroalkyl Iodides to Construct β-Perfluoroalkyl Alcohols

被引：0

作者：

Zhang, Jiantao ^{[1
]}

Zhu, Weiming ^{[1
]}

Su, Renhua ^{[1
]}

Xiao, Duoduo ^{[1
]}

Zhou, Peng ^{[1
]}

Chen, Kai ^{[3
]}

Zhang, Min ^{[2
]}

Chen, Cui ^{[1
]}

Liu, Weibing ^{[1
]}

机构：

[1] Guangdong Univ Petrochem Technol, Coll Chem, Maoming 525000, Guangdong, Peoples R China

[2] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China

[3] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Allyl Alcohols; 1,3-Dienes; Mono-Olefins; 1,3-Enynes; TBHP; ONE-POT SYNTHESIS; MEDICINAL CHEMISTRY; FLUORINE; FLUOROALKYLATION; STYRENES; OLEFINS;

D O I：

10.1002/adsc.202400218

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A three-component strategy for the synthesis of beta-perfluoroalkyl allyl alcohols from 1,3-dienes is developed. A diverse range of synthetically valuable beta-perfluoroalkyl allyl alcohols are obtained in moderate to high yields. Broad substrate scope and good functional group tolerance are observed. This method is also applicable to mono-olefins and 1,3-enynes. The control experiment results demonstrate that the hydroxyl group OH in the product comes from TBHP. In addition, the practicality and mild reaction conditions make these synthetic transformations attractive and valuable for organic synthesis. image

引用

页码：3572 / 3577

页数：6