Potassium tert-butoxide promoted a direct one-pot synthesis of nitriles from aldehydes at room temperature

被引：0

作者：

Kumar, Saurav ^{[1
]}

Kubba, Ritika ^{[1
]}

Agasti, Nityananda ^{[2
]}

Selvaraj, Anitha ^{[3
]}

Kumar, Anil ^{[1
]}

机构：

[1] Delhi Technol Univ, Dept Appl Chem, Delhi 110042, India

[2] Univ Delhi, Deen Dayal Upadhyaya Coll, Dept Chem, Delhi 110078, India

[3] Sri Sai Ram Engn Coll, Dept Phys, Chennai 600044, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2024年 / 136卷 / 02期

关键词：

nitrile; benzaldehyde; hydroxyl amine; benzoyl chloride; potassium tert-butoxide; CATALYZED CYANATION; PRIMARY AMIDES; DEHYDRATION; ALDOXIMES; CONVERSION; EFFICIENT; ROLES;

D O I：

10.1007/s12039-024-02282-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Potassium tert-butoxide mediated a direct one-pot synthesis of diversely substituted nitriles from aldehydes via the sequential addition of hydroxylamine and benzoyl chloride is reported. A wide range of aromatic, heteroaromatic, and vinyl aldehydes were converted into corresponding nitriles in good to excellent yields. Room temperature reactions, transition metal-free conditions, wide functional group tolerance, simple operation, and short reaction time are the salient features of the developed methodology.

引用

页数：6

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