Synthesis, Crystal Structure and Biological Evaluation of Acridine-1,2,3-triazole Derivatives

被引：2

作者：

霍丽妮 ^{[1
,2
]}

陈睿 ^{[3
]}

廖艳芳 ^{[4
]}

刘华钢 ^{[2
]}

李培源 ^{[1
]}

卢汝梅 ^{[1
]}

钟振国 ^{[1
]}

机构：

[1] College of Pharmacy, Guangxi University of Chinese Medicine

[2] Guangxi Medical University

[3] Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine

[4] Guangxi Research Institute of Chemical Industry

来源：

结构化学 | 2016年 / 35卷 / 05期

基金：

中国国家自然科学基金;

关键词：

acridine-1,2,3-triazole; crystal structure; antitumor activities;

D O I：

暂无

中图分类号：

O626.26 [三氮杂茂（三唑）];

学科分类号：

070303 ; 081704 ;

摘要：

A series of acridine-1,2,3-triazole derivatives were designed, synthesized and characterized by NMR. 1-（2-methylacridinyl）-4-（4-methyl phenyl）-1,2,3-triazole（4f）, C;H;N;, was structurally determined by single-crystal X-ray diffraction. It crystallizes in the triclinic system, space group P1 with a = 9.585（4）, b = 9.684（4）, c = 11.339（5） ?, β = 88.250（7）o, V = 925.3（6）, Z = 2, D;= 1.258 g/cm;, F（000） = 368, μ = 0.077 mm;, the final R = 0.0808 and wR = 0.2218 for 3386 observed reflections(I > 2σ（I）). X-ray analysis indicates that the acridine ring is almost vertical to triazole ring with the dihedral angle nearly to be 75°. The crystal packing of the compound is stabilized mainly by π-π interaction. The preliminary biological tests display that some of the title compounds possess a good anti-tumour activity against MGC-803 and T24.

引用

页码：698 / 704

页数：7

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