Lactate: an intracellular metabolite regulates cell cycle progression

<正>The Chouchani lab recently reported in Nature that a dynamic intracellular lactate is a physiological regulator for cell cycle progress. They also showed that accumulated lactate in cell mitosis directly binds and inhibits Sentrin/SUMO-specific protease 1 to enrich SUMO2/3-modification of anaphase-promoting complex 4(APC4), which promotes the degradation of APC/C complexes, leading to mitosis exit.Cellular metabolism is an important driver of cellular activities [1]. On the one hand, cellular metabolism adjusts to meet the needs of cellular activity [1]. For example, in proliferating cells, aerobic glycolytic metabolism increases, and the intermediate products of glycolytic metabolism are used as building blocks for synthesis of macromolecules needed for cell proliferation.