Enantioselective benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes

被引：0
|
作者：
HUANG XueLiang YE Song Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry Chinese Academy of Sciences Beijing China [100190 ]
机构：
来源：
Chinese Science Bulletin | 2010年 / 55卷 / 17期
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中图分类号：
O643.3 [催化];
学科分类号：
081705 ;
摘要：
Benzoin condensation is an important carbon-carbon bond-forming reaction. The benzoin reaction with good yield, high enantioselectivity and broad substrate scope is highly desired in organic synthesis. The intermolecular benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes has been investigated, and the corresponding α-hydroxyketones were obtained with yields up to 76% and enantioselectivities up to 99% ee.
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页码：1753 / 1757
页数：5
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