THERAPEUTIC EFFICACY OF ORAL LOW-DOSE CYCLOSPORINE A IN SEVERE PSORIATIC-ARTHRITIS

被引:20
|
作者
WAGNER, SA
PETER, RU
ADAM, O
RUZICKA, T
机构
[1] UNIV MUNICH,DEPT DERMATOL,FRAUENLOBSTR 9-11,W-8000 MUNICH 2,GERMANY
[2] UNIV MUNICH,DEPT RHEUMATOL,W-8000 MUNICH 2,GERMANY
关键词
PSORIASIS; PSORIATIC ARTHRITIS; CYCLOSPORINE-A SIDE EFFECTS;
D O I
10.1159/000247305
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Six male patients with severe psoriatic arthritis (PA) unresponsive to various topical and systemic therapies have been treated with oral cyclosporin A (CyA; Sandimmun(R)) solution at daily doses ranging usually from 1.5 to 5.0 mg/kg. In 1 case the dose had to be increased to 7 mg/kg/day. At initiation of CyA therapy skin involvement was between 40 and 90% of total body surface. Initiation of CyA therapy resulted in marked improvement of skin lesions within 2-7 weeks accompanied by impressive relief from arthralgias and improvement of joint function. The requirement for nonsteroidal anti-inflammatory drugs was markedly reduced in all cases. All patients in whom CyA therapy was continued remained clinically stable for several months (follow-up period 2-7 months). Although mild to moderate relapses occurred, rebound phenomena were not observed after discontinuation of treatment. Side effects which comprised serum creatinine increases in 3 out of 6 cases were reversed by adjustment of CyA dosage.
引用
收藏
页码:62 / 67
页数:6
相关论文
共 50 条
  • [21] LOW INCIDENCE OF HEPATOTOXICITY ASSOCIATED WITH LONG-TERM, LOW-DOSE ORAL METHOTREXATE IN TREATMENT OF REFRACTORY PSORIASIS, PSORIATIC-ARTHRITIS, AND RHEUMATOID-ARTHRITIS - AN ACCEPTABLE RISK BENEFIT RATIO
    LANSE, SB
    ARNOLD, GL
    GOWANS, JDC
    KAPLAN, MM
    DIGESTIVE DISEASES AND SCIENCES, 1985, 30 (02) : 104 - 109
  • [22] LOW-DOSE CYCLOSPORINE FOR SEVERE APLASTIC-ANEMIA
    MEHTA, J
    SINGHAL, S
    MEHTA, BC
    AMERICAN JOURNAL OF HEMATOLOGY, 1992, 40 (01) : 73 - 73
  • [23] THERAPEUTIC VALUE OF COLCHICINE IN THE TREATMENT OF PATIENTS WITH PSORIATIC-ARTHRITIS
    MCKENDRY, RJR
    KRAAG, G
    SEIGEL, S
    ALAWADHI, A
    ANNALS OF THE RHEUMATIC DISEASES, 1993, 52 (11) : 826 - 828
  • [24] PSORIATIC-ARTHRITIS TREATED WITH ORAL ZINC-SULFATE
    CLEMMENSEN, OJ
    SIGGAARDANDERSEN, J
    WORM, AM
    STAHL, D
    FROST, F
    BLOCH, I
    BRITISH JOURNAL OF DERMATOLOGY, 1980, 103 (04) : 411 - 415
  • [25] LONG-TERM NEPHROTOXICITY OF CYCLOSPORINE-A (CY A) IN PSORIATIC-ARTHRITIS
    DONNELLY, S
    DOYLE, DV
    ARTHRITIS AND RHEUMATISM, 1992, 35 (09): : S106 - S106
  • [26] THE EFFICACY OF HEALTH RESORT MANAGEMENT OF PSORIATIC-ARTHRITIS IN EVPATORIA
    MILYAVSKY, AI
    LOSEV, VB
    PERELMUTER, DL
    RUZHKOVA, MA
    NEREVYATKIN, GK
    EDIGAROVA, IS
    VESTNIK DERMATOLOGII I VENEROLOGII, 1989, (01) : 42 - 44
  • [27] THE EFFICACY OF DICLONATE-P IN THE TREATMENT OF PSORIATIC-ARTHRITIS
    BURDEINY, AP
    TERAPEVTICHESKII ARKHIV, 1994, 66 (05) : 75 - 77
  • [28] CYCLOSPORINE-A BENEFITS BOTH SKIN AND JOINT DISEASE IN PSORIATIC-ARTHRITIS
    SCHOPF, RE
    BRAUTIGAM, M
    MORSCHES, B
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (04) : 616 - 616
  • [29] FOLIC-ACID AND CYANOCOBALAMIN LEVELS IN SERUM AND ERYTHROCYTES DURING LOW-DOSE METHOTREXATE THERAPY OF RHEUMATOID-ARTHRITIS AND PSORIATIC-ARTHRITIS PATIENTS
    LEEB, BF
    WITZMANN, G
    OGRIS, E
    STUDNICKABENKE, A
    ANDEL, I
    SCHWEITZER, H
    SMOLEN, JS
    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 1995, 13 (04) : 459 - 463
  • [30] SHORT-TERM, HIGH-DOSE METHOTREXATE THERAPY IN A CASE OF SEVERE PSORIATIC-ARTHRITIS
    EECKHOUT, E
    SUYS, E
    BUYDENS, P
    VANBELLE, S
    VERBRUGGEN, LA
    BRITISH JOURNAL OF RHEUMATOLOGY, 1988, 27 (02): : 160 - 162