AN EFFICIENT SYNTHESIS OF THE BENZHYDRYLPIPERAZINE DELTA-OPIOID AGONIST (+)-BW373U86

被引：66
|
作者：
BISHOP, MJ
MCNUTT, RW
机构：
[1] Division of Organic Chemistry, Burroughs Wellcome Co., Research Triangle Park
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 12期
关键词：
D O I：
10.1016/0960-894X(95)00213-D
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A diastereoselective version of Katritzky's method for tertiary amine formation provides an efficient route to the highly selective, non-peptidal, delta opioid agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl]-N,N-diethylbenzamide[(+)-BW373U86], 1.
引用
收藏
页码：1311 / 1314
页数：4
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