A RANDOMIZED PLACEBO-CONTROLLED DOUBLE-BLIND-STUDY OF DANAZOL IN HEMOPHILIA-A

被引：0
|
作者：
MEHTA, J [1 ]
SINGHAL, S [1 ]
KAMATH, MV [1 ]
MEHTA, BC [1 ]
机构：
[1] KING EDWARD MEM HOSP,DEPT HEMATOL,BOMBAY,INDIA
来源：
ACTA HAEMATOLOGICA | 1992年 / 88卷 / 01期
关键词：
DANAZOL; FACTOR VIII C; HEMOPHILIA-A;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A randomized double-blind placebo-controlled crossover trial of danazol was carried out in 19 cases of hemophilia A. Danazol was given for 3 months at a dose of 150 mg/day to patients under 15 years of age, and 300 mg/day to older patients. The basal factor VIII:C level was 8.3 +/- 5.6% (mean +/- SD), and after 3 months of danazol treatment was 15.3 +/- 11.0% (p = 0.02). Six patients (basal factor VIII:C 2-22%) showed a 1.36- to 2.87-fold elevation of factor VIII:C levels after danazol. 0/2, 1/4 and 5/13 cases of severe, moderate and mild disease, respectively, responded. Decreases in the number of bleeding episodes and cryoprecipitate requirement were seen in the responders. No adverse reactions to danazol were encountered. Danazol appears to raise the factor VIII:C levels in selected cases of hemophilia A.
引用
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页码：14 / 16
页数：3
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