EFFECTS OF MUSCIMOL AND FLURAZEPAM ON THE SLEEP EEG IN THE RAT

被引：13
|
作者：
MENDELSON, WB
MARTIN, JV
机构：
[1] Dept. of Psychiatry, State University of New York at Stony Brook, Health Sciences Center, Stony Brook, NY 11794-8101
来源：
LIFE SCIENCES | 1990年 / 47卷 / 19期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1016/0024-3205(90)90354-T
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In order to assess the possible role of GABA receptor function in the hypnotic property of benzodiazepines, we have examined the sleep EEG in rats given the GABA agonist muscimol, alone and in combination with flurazepam. Muscimol 0.05 and 0.1 mg/kg IP failed to alter sleep latency or total sleep time, and did not interact with the sleep-enhancing properties of flurazepam 20 mg/kg IP. These observations, in conjunction with a previous study of bicuculline, suggest that the hypnotic property of benzodiazepines may not be mediated by alteration of GABAergic activity. © 1990.
引用
收藏
页码：PL99 / PL101
页数：3
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