Rational Polytherapy with Antiepileptic Drugs

被引：54

作者：

Lee, Jong Woo ^{[1
]}

Dworetzky, Barbara ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Edward B Bromfield Epilepsy Program, Div EEG Epilepsy & Sleep Neurol, Dept Neurol, 75 Francis St, Boston, MA 02115 USA

来源：

PHARMACEUTICALS | 2010年 / 3卷 / 08期

关键词：

antiepileptic drug; rational polytherapy; epilepsy;

D O I：

10.3390/ph3082362

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Approximately 30-40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy.

引用

页码：2362 / 2379

页数：18

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