A NOVEL SUSTAINED-RELEASE FORMULATION OF IBUPROFEN PROVIDES EFFECTIVE ONCE-DAILY THERAPY IN THE TREATMENT OF RHEUMATOID-ARTHRITIS AND OSTEOARTHRITIS

被引：0
|
作者：
OCONNOR, TP
ANDERSON, AMR
LENNOX, B
MULDOON, C
机构：
[1] BOOTS PHARMACEUT,CLIN INVEST,NOTTINGHAM NG2 3AA,ENGLAND
[2] HLTH CTR,PAISLEY,RENFREW,SCOTLAND
[3] ST MARYS HLTH CTR,PRESTON,ENGLAND
来源：
BRITISH JOURNAL OF CLINICAL PRACTICE | 1993年 / 47卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The efficacy and safety of a novel sustained-release formulation of ibuprofen given once-daily was compared with conventional-release ibuprofen tablets 400 mg given four times daily, in a single-blind, parallel-group study. This study was conducted at 84 general practice centres throughout the UK among patients with osteoarthritis or rheumatoid arthritis. An unequal randomisation in the ratio of 4:1 was carried out, with 463 patients who received sustained-release and 115 who received conventional-release ibuprofen providing evaluable data. In this study sustained-release ibuprofen was shown to be a more effective alternative to conventional ibuprofen therapy for the treatment of arthritic diseases in general practice, offering the convenience of once-daily dosing and the associated potential benefit of improved patient compliance.
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页码：10 / 13
页数：4
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