Regulatory Mechanisms of Chondrogenesis and Implications for Understanding Articular Cartilage Homeostasis

被引：15
|
作者：
Hidaka, Chisa [1 ]
Goldring, Mary B. [1 ]
机构：
[1] Hosp Special Surg, Tissue Engn Regenerat & Repair Program, New York, NY 10021 USA
来源：
CURRENT RHEUMATOLOGY REVIEWS | 2008年 / 4卷 / 03期
关键词：
Aging; Chondrogenesis; Homeostasis; In articular cartilage; Osteoarthritis; Pathogenesis;
D O I：
10.2174/157339708785133541
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Studies of chondrogenesis and embryonic limb development offer a wealth of knowledge regarding signals that regulate the behavior of chondrocytes. Many such chondrogenic regulators are upregulated in osteoarthritis-affected chondrocytes, suggesting a role in pathogenesis. Yet, some of the same factors also support adult articular cartilage homeostasis, and enhance neo-cartilage tissue formation in experimental models. In this review, we summarize many of the important regulatory mechanisms involved in chondrogenesis and examine how their disruption may contribute to functional changes in articular cartilage during osteoarthritis or aging.
引用
收藏
页码：136 / 147
页数：12
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