PHYSICAL EXERCISE AS A NOVEL ANTIDEPRESSANT AGENT - POSSIBLE ROLE OF SEROTONIN RECEPTOR SUBTYPES

被引:43
|
作者
DEY, S
机构
[1] BANARAS HINDU UNIV, DEPT PHYSIOL, NEUROPHYSIOL UNIT, VARANASI 221005, UTTAR PRADESH, INDIA
[2] BANARAS HINDU UNIV, INST MED SCI, DEPT KAYACHIKITSA, VARANASI 221005, UTTAR PRADESH, INDIA
关键词
EXERCISE TRAINING; 5-HT RECEPTORS; ANTIDEPRESSANTS; DEPRESSION; 5-HT SYNDROME; WET DOG RESPONSE; STRESS;
D O I
10.1016/0031-9384(94)90141-4
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Long-term exercise is associated with an antidepressant effect in patients with mild to moderate forms of nonbipolar depression and appears to be a promising new approach to its treatment. Adaptive changes in serotonin (5-HT) receptor functioning appears to play an important role in mediating the action of various antidepressant treatments. We investigated the adaptive changes in behavioral sensitivity of the 5-HT receptor subtype following 4 weeks of swimming exercise in normal rats, as well as in an animal model of depression (3 week, variety of chronic stressors). 5-HT1A autoreceptor sensitivity was assessed by hyperphagic response induced by 8-OH-DPAT (0.25 mg/kg, IP); 5-HT1A postsynaptic receptor by 5-HT syndrome induced by 8-OH-DPAT (0.75 mg/kg, IP), and 5 Me-ODMT (5 mg/kg, IP); and 5-HT2 receptor by wet dog shakes response induced by quipazine (1 mg/kg, IP) and 5MeODMT (5 mg/kg, IP). It was observed that exercise training in normal rats resulted in enhanced sensitivity of the 5-HT2 receptors along with subsensitivity of 5-HT,, autoreceptors. Exercise, given prophylactically along with chronic stressors, was able to prevent the development of behavioral deficit in the open-field test, and the animals developed remarkably enhanced sensitivity of 5-HT2 receptors. This adaptive supersensitivity of 5-HT2 receptor is also seen after various antidepressant treatments and may play an important role in mediating the antidepressant action of exercise.
引用
收藏
页码:323 / 329
页数:7
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