DIRECT OBSERVATION OF REVERSE TRANSCRIPTASES BY SCANNING TUNNELING MICROSCOPY

被引：8

作者：

LEWERENZ, HJ ^{[1
]}

JUNGBLUT, H ^{[1
]}

CAMPBELL, SA ^{[1
]}

GIERSIG, M ^{[1
]}

MULLER, DJ ^{[1
]}

机构：

[1] PORTSMOUTH POLYTECH,DEPT CHEM,PORTSMOUTH PO1 2DT,ENGLAND

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1992年 / 8卷 / 09期

关键词：

D O I：

10.1089/aid.1992.8.1663

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

First images on a nanometer scale of reverse transcriptases (RT) of the human immunodeficiency virus (HIV-1) and of the Moloney murine leukemia virus (MuLV) obtained by scanning tunneling microscopy (STM) are reported. The common feature of the observed molecules is a ring-type or horseshoe shape with hole diameters of almost-equal-to 30 angstrom. The STM images are compared with high resolution transmission electron microscopy (TEM) and existing structure predictions. The similarities of the structural data obtained by STM and TEM and their agreement with the structure prediction for the RT of HIV-1 shows the principal possibility to image such biomolecules by STM.

引用

页码：1663 / 1667

页数：5

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