Diagnostic and prognostic value of autoantibodies for diabetes mellitus. A novel T1D autoimmunity target - zinc transporter 8 (ZnT8)

被引：0

作者：

Shapovalyants, O. S. ^{[1
]}

Nikonova, T. V. ^{[1
]}

机构：

[1] Endocrinol Res Ctr, Moscow, Russia

来源：

DIABETES MELLITUS | 2011年 / 14卷 / 02期

关键词：

type 1 mellitus diabetes; autoantibodies; immunnity; zinc transporter 8;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The progressive loss of beta cells in Type 1 Diabetes (T1D) is a result of chronic autoimmune attack targeted at diverse molecules expressing in the pancreatic beta cells. The appearance of cellular and humoral autoimmunity precedes the clinical manifestation of T1D. There are several autoantigens which are supposed to be involved in pathogenesis of TD1. Zinc transporter 8 (ZnT8; Slc30A8) was identified as a novel T1D autoimmunity target.

引用

页码：18 / 22

页数：5

共 33 条

[31] The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes
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Endocrine, 2016, 53 : 740 - 746
[32] Anti-zinc transporter protein 8 autoantibodies significantly improve the diagnostic approach to type 1 diabetes: an Italian multicentre study on paediatric patients
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Zago, Silvia
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AUTOIMMUNITY HIGHLIGHTS, 2015, 6 (1-2) : 17 - 22
[33] A Novel Association between Zinc Transporter 8 Arginine Autoantibodies and Ptpn22 Polymorphisms in a Multiethnic Population of Type 1 Diabetes Patients and their First Degree Relatives
Araujo, Debora Batista
Skarstrand, Hanna
Barone, Bianca
Dantas, Joana
Kupfer, Rosane
Zajdenverg, Lenita
Milech, Adolpho
Sani, Fariba Vaziri
De Oliveira, Jose Egidio Paulo
Rodacki, Melanie
DIABETES, 2013, 62 : A446 - A447

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