Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa

被引：7

作者：

Tantry, Mudasir A. ^{[1
,4
]}

Idris, Ahmed S. ^{[2
,7
]}

Williamson, John S. ^{[2
]}

Shafi, Tasfi ^{[3
]}

Dar, Jehangir S. ^{[4
]}

Malik, Tauseef A. ^{[4
,5
]}

Ganai, Bashir A. ^{[4
]}

Shawl, Abdul S. ^{[6
]}

机构：

[1] Cluster Univ Srinagar, SP Coll, Dept Chem, Srinagar 190001, Kashmir, India

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[3] Univ Bhopal, MLB Coll, Dept Zool, Bhopal 462026, India

[4] Univ Kashmir, Res Dev Ctr, Phytochem Labs, Srinagar 190006, Kashmir, India

[5] Cluster Univ Srinagar, Govt Coll Women, Dept Zool, Srinagar 190001, Kashmir, India

[6] CSIR Indian Inst Integrat Med, Nat Prod Chem Div, Srinagar 190005, Kashmir, India

[7] Univ Benghazi, Coll Pharm, Dept Pharmaceut Chem, Benghazi 16063, Libya

来源：

HELIYON | 2018年 / 4卷 / 12期

关键词：

Natural product chemistry;

D O I：

10.1016/j.heliyon.2018.e01046

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1) and 3,6,6a,7,10-pentahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (2). Structure of compounds 1-2 was determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antimicrobial, antileismanial, antimalarial and cytotoxic activities of compound 1 and 2 were evaluated.

引用

页数：11

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