Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa

被引：7
|
作者：
Tantry, Mudasir A. [1 ,4 ]
Idris, Ahmed S. [2 ,7 ]
Williamson, John S. [2 ]
Shafi, Tasfi [3 ]
Dar, Jehangir S. [4 ]
Malik, Tauseef A. [4 ,5 ]
Ganai, Bashir A. [4 ]
Shawl, Abdul S. [6 ]
机构：
[1] Cluster Univ Srinagar, SP Coll, Dept Chem, Srinagar 190001, Kashmir, India
[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA
[3] Univ Bhopal, MLB Coll, Dept Zool, Bhopal 462026, India
[4] Univ Kashmir, Res Dev Ctr, Phytochem Labs, Srinagar 190006, Kashmir, India
[5] Cluster Univ Srinagar, Govt Coll Women, Dept Zool, Srinagar 190001, Kashmir, India
[6] CSIR Indian Inst Integrat Med, Nat Prod Chem Div, Srinagar 190005, Kashmir, India
[7] Univ Benghazi, Coll Pharm, Dept Pharmaceut Chem, Benghazi 16063, Libya
来源：
HELIYON | 2018年 / 4卷 / 12期
关键词：
Natural product chemistry;
D O I：
10.1016/j.heliyon.2018.e01046
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1) and 3,6,6a,7,10-pentahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (2). Structure of compounds 1-2 was determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antimicrobial, antileismanial, antimalarial and cytotoxic activities of compound 1 and 2 were evaluated.
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页数：11
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