ATOMIC-STRUCTURE OF THE ACTIN - DNASE-I COMPLEX

被引：1645
作者：
KABSCH, W
MANNHERZ, HG
SUCK, D
PAI, EF
HOLMES, KC
机构：
[1] EUROPEAN MOLEC BIOL LAB,W-6900 HEIDELBERG,GERMANY
[2] UNIV MARBURG,INST ANAT & ZELLBIOL,W-3550 MARBURG,GERMANY
来源：
NATURE | 1990年 / 347卷 / 6288期
关键词：
D O I：
10.1038/347037a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The atomic models of the complex between rbonuclease I both in the ATP and ADP forms have been determined byo X-ray analysis at an effective resolution of 2.8 Å and 3 Å, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the β- or β- and γ-phosphates, respectively. The motif of a five-stranded (3 sheet consisting of a (3 meander and a right handed βαβ unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase. © 1990 Nature Publishing Group.
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页码：37 / 44
页数：8
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